Established and emerging concepts in Hirschsprung’s-associated enterocolitis

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Hirschsprung’s disease (HSCR) is a common cause of neonatal bowel obstruction and the approach to diagnosis and surgical treatment is well defined and accepted. Hirschsprung’s-associated enterocolitis (HAEC) remains a frequent cause of pre-operative and post-operative morbidity and mortality, with unchanged treatment guidelines over multiple decades. Recent advances in our understanding of the genetics underlying HSCR have allowed the development of animal models, some of which recapitulate the HAEC phenotype. These animal models, along with recent translational studies, have implicated multiple facets of mucosal immunity and microbiome dysbiosis in the development of HAEC. Here, we will review the established epidemiology, modes of diagnosis and treatment of HAEC. Furthermore, we will explore emerging concepts in the pathogenesis of this disease; including animal models, alterations in mucosal immunity, dysbiosis of the intestinal microbiome, specific genetic susceptibility, and novel treatment modalities.

Original languageEnglish (US)
Pages (from-to)313-320
Number of pages8
JournalPediatric Surgery International
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2016

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Enterocolitis
Dysbiosis
Hirschsprung Disease
Mucosal Immunity
Animal Models
Microbiota
Genetic Predisposition to Disease
Epidemiology
Guidelines
Morbidity
Phenotype
Mortality

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Established and emerging concepts in Hirschsprung’s-associated enterocolitis. / Gosain, Ankush.

In: Pediatric Surgery International, Vol. 32, No. 4, 01.04.2016, p. 313-320.

Research output: Contribution to journalReview article

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