Estimation of regional activation maps and interdependencies from minimum norm estimates of magnetoencephalography (MEG) data

Abdou Mousas, Panagiotis G. Simos, Roozbeh Rezaie, Andrew Papanicolaou

Research output: Contribution to journalArticle

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Abstract

Here, we describe the development of a minimally supervised pipeline for the analysis of event-related magnetoencephalography (MEG) recordings that preserves the temporal resolution of the data and enables estimation of patterns of regional interdependencies between activated regions. The method was applied to MEG recordings obtained from six right-handed young adults performing an overt naming task using a whole-head system with 248 axial magnetometers. Minimum norm estimates of distributed source currents were calculated in Brainstorm during the first 400 ms post-stimulus onset. A spatiotemporal sourceclustering algorithm was applied to identify extended regions of significant activation as compared to the prestimulus baseline for each participant. Finally, regional interdependencies were estimated through crosslag correlation analysis between time-series representing the time course of activity within each cluster. Consistently across participants activation loci were found in primary and association visual cortices, the fusiform and lingual gyri, the posterior portion of the superior and middle temporal gyri (MTG), the anterior, middle-inferior temporal lobe (ITG), and the inferior (IFG) and middle frontal gyri (MFG). Regions where dynamic activation patterns appeared to be “affected” by prior activation in primary/ association visual cortices and the fusiform gyrus were found in the MTG/anterior ITG, and MFG. Immediately prior to articulation, activations were found in IFG, ITG, fusiform and supramarginal gyri.

Original languageEnglish (US)
Pages (from-to)267-289
Number of pages23
JournalNeuromethods
Volume91
DOIs
StatePublished - Jan 1 2015

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Magnetoencephalography
Temporal Lobe
Chemical activation
Visual Cortex
Association reactions
Time series analysis
Magnetometers
Occipital Lobe
Parietal Lobe
Pipelines
Young Adult
Head

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

Cite this

Estimation of regional activation maps and interdependencies from minimum norm estimates of magnetoencephalography (MEG) data. / Mousas, Abdou; Simos, Panagiotis G.; Rezaie, Roozbeh; Papanicolaou, Andrew.

In: Neuromethods, Vol. 91, 01.01.2015, p. 267-289.

Research output: Contribution to journalArticle

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