Estrogen and progesterone induce migration, invasion, and proliferation of vascular smooth muscle cells via matrix metalloproteinase regulation

Deidra Mountain, Stacy S. Kirkpatrick, David C. Cassada, Scott Stevens, Michael Freeman, Mitchell Goldman, Oscar Grandas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Recent studies have indicated postmenopausal women receiving hormone replacement therapy (HRT) have more adverse outcomes of peripheral arterial disease after vascular reconstruction, including increased intimal hyperplasia (IH) and restenosis. The major cellular processes contributing to IH pathogenesis are extracellular matrix (ECM) degradation and vascular smooth muscle cell (VSMC) proliferation, migration, and invasion of the ECM. We have previously shown hormone exposure results in unbalanced matrix metalloproteinase (MMP) regulation in VSMCs, a family of ECM degradative enzymes known to play a role in vascular remodeling. Here we examine the role of hormonally-stimulated MMP activity in the regulation of the cellular processes contributing to IH development. Data from the type of analyses presented here could be used to develop a computational model of vascular restenosis focusing on the importance of hormone-modulated VSMC function.

Original languageEnglish (US)
Title of host publication2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
DOIs
StatePublished - Oct 20 2009
Event2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009 - Oak Ridge, TN, United States
Duration: Mar 18 2009Mar 19 2009

Other

Other2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
CountryUnited States
CityOak Ridge, TN
Period3/18/093/19/09

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Tunica Intima
Matrix Metalloproteinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Extracellular Matrix
Progesterone
Muscle
Estrogens
Cells
Hormones
Blood Vessels
Peripheral Arterial Disease
Hormone Replacement Therapy
Cell Movement
Cell Proliferation
Cell proliferation
Enzymes
Metalloproteases
Degradation

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Estrogen and progesterone induce migration, invasion, and proliferation of vascular smooth muscle cells via matrix metalloproteinase regulation. / Mountain, Deidra; Kirkpatrick, Stacy S.; Cassada, David C.; Stevens, Scott; Freeman, Michael; Goldman, Mitchell; Grandas, Oscar.

2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009. 2009. 5090490.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mountain, D, Kirkpatrick, SS, Cassada, DC, Stevens, S, Freeman, M, Goldman, M & Grandas, O 2009, Estrogen and progesterone induce migration, invasion, and proliferation of vascular smooth muscle cells via matrix metalloproteinase regulation. in 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009., 5090490, 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009, Oak Ridge, TN, United States, 3/18/09. https://doi.org/10.1109/BSEC.2009.5090490
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AU - Freeman, Michael

AU - Goldman, Mitchell

AU - Grandas, Oscar

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