Estrogen receptors alpha and beta in bone

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts of the receptors. In vitro and in vivo experiments have shown that ERα and ERβ antagonize each other in bone and in other tissues. This review will highlight the role of these receptors in bone, with particular emphasis on their antagonism.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalBone
Volume87
DOIs
StatePublished - Jun 1 2016

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Estrogen Receptor beta
Estrogen Receptor alpha
Bone and Bones
Estrogens
Osteocytes
Osteoclasts
Osteoblasts
Bone Density

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Estrogen receptors alpha and beta in bone. / Khalid, Aysha; Miranda, Susan.

In: Bone, Vol. 87, 01.06.2016, p. 130-135.

Research output: Contribution to journalReview article

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