Estrogen replacement, muscle composition, and physical function: The health ABC study

Dennis R. Taaffe, Anne B. Newman, Catherine L. Haggerty, Lisa H. Colbert, Nathalie De Rekeneire, Marjolein Visser, Bret H. Goodpaster, Michael C. Nevitt, Frances Tylavsky, Tamara B. Harris

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: Although the beneficial effects of estrogen use on cardiovascular and cognitive function in postmenopausal women have been recently discredited, controversy remains regarding its usefulness for maintaining skeletal muscle mass or strength. Therefore, the purpose of this study was to determine whether estrogem use is associated with enhanced muscle composition and, if so, whether this translates into improved strength and physical function. Methods: Cross-sectional analysis of 840 well-functioning community-dwelling white women (current estrogen replacement therapy (ERT) users = 259, nonusers = 581) aged 70-79 yr participating in the Health, Aging and Body Composition Study. Muscle composition of the midthigh by computed tomography included cross-sectional area (CSA) of the quadriceps, hamstrings, intermuscular fat and subcutaneous fat, and muscle attenuation in Hounsfield units (HU) as a measure of muscle density. Isometric hand grip and isokinetic knee extensor strength were assessed by dynamometry. Physical function was assessed using a summary scale that included usual 6-m walk and narrow walk speed, repeated chair stands, and standing balance. Results: In analyses of covariance adjusted for relevant confounders, quadriceps muscle CSA and HU were greater in current ERT than non-ERT women (P < 0.05). Grip strength was also greater (P < 0.05) in women taking ERT while knee extensor strength approached significance (P < 0.10). However, differences in muscle composition and strength were modest at ≤3.3%. There was no difference by ERT status for the hamstring muscles, fat CSA, or for physical function. Conclusion: The associations between ERT and muscle composition and strength were minor and did not translate into improved physical function. Initiation of ERT for preservation of muscle composition and function may not be indicated.

Original languageEnglish (US)
Pages (from-to)1741-1747
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume37
Issue number10
DOIs
StatePublished - Oct 1 2005

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Estrogen Replacement Therapy
Muscles
Health
Muscle Strength
Hand Strength
Knee
Fats
Independent Living
Subcutaneous Fat
Quadriceps Muscle
Body Composition
Cognition
Estrogens
Skeletal Muscle
Hand
Cross-Sectional Studies
Tomography

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Taaffe, D. R., Newman, A. B., Haggerty, C. L., Colbert, L. H., De Rekeneire, N., Visser, M., ... Harris, T. B. (2005). Estrogen replacement, muscle composition, and physical function: The health ABC study. Medicine and Science in Sports and Exercise, 37(10), 1741-1747. https://doi.org/10.1249/01.mss.0000181678.28092.31

Estrogen replacement, muscle composition, and physical function : The health ABC study. / Taaffe, Dennis R.; Newman, Anne B.; Haggerty, Catherine L.; Colbert, Lisa H.; De Rekeneire, Nathalie; Visser, Marjolein; Goodpaster, Bret H.; Nevitt, Michael C.; Tylavsky, Frances; Harris, Tamara B.

In: Medicine and Science in Sports and Exercise, Vol. 37, No. 10, 01.10.2005, p. 1741-1747.

Research output: Contribution to journalArticle

Taaffe, DR, Newman, AB, Haggerty, CL, Colbert, LH, De Rekeneire, N, Visser, M, Goodpaster, BH, Nevitt, MC, Tylavsky, F & Harris, TB 2005, 'Estrogen replacement, muscle composition, and physical function: The health ABC study', Medicine and Science in Sports and Exercise, vol. 37, no. 10, pp. 1741-1747. https://doi.org/10.1249/01.mss.0000181678.28092.31
Taaffe, Dennis R. ; Newman, Anne B. ; Haggerty, Catherine L. ; Colbert, Lisa H. ; De Rekeneire, Nathalie ; Visser, Marjolein ; Goodpaster, Bret H. ; Nevitt, Michael C. ; Tylavsky, Frances ; Harris, Tamara B. / Estrogen replacement, muscle composition, and physical function : The health ABC study. In: Medicine and Science in Sports and Exercise. 2005 ; Vol. 37, No. 10. pp. 1741-1747.
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AU - De Rekeneire, Nathalie

AU - Visser, Marjolein

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AU - Tylavsky, Frances

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N2 - Purpose: Although the beneficial effects of estrogen use on cardiovascular and cognitive function in postmenopausal women have been recently discredited, controversy remains regarding its usefulness for maintaining skeletal muscle mass or strength. Therefore, the purpose of this study was to determine whether estrogem use is associated with enhanced muscle composition and, if so, whether this translates into improved strength and physical function. Methods: Cross-sectional analysis of 840 well-functioning community-dwelling white women (current estrogen replacement therapy (ERT) users = 259, nonusers = 581) aged 70-79 yr participating in the Health, Aging and Body Composition Study. Muscle composition of the midthigh by computed tomography included cross-sectional area (CSA) of the quadriceps, hamstrings, intermuscular fat and subcutaneous fat, and muscle attenuation in Hounsfield units (HU) as a measure of muscle density. Isometric hand grip and isokinetic knee extensor strength were assessed by dynamometry. Physical function was assessed using a summary scale that included usual 6-m walk and narrow walk speed, repeated chair stands, and standing balance. Results: In analyses of covariance adjusted for relevant confounders, quadriceps muscle CSA and HU were greater in current ERT than non-ERT women (P < 0.05). Grip strength was also greater (P < 0.05) in women taking ERT while knee extensor strength approached significance (P < 0.10). However, differences in muscle composition and strength were modest at ≤3.3%. There was no difference by ERT status for the hamstring muscles, fat CSA, or for physical function. Conclusion: The associations between ERT and muscle composition and strength were minor and did not translate into improved physical function. Initiation of ERT for preservation of muscle composition and function may not be indicated.

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