Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus

Ramareddy Guntaka, Brian W.J. Mahy, J. Michael Bishop, Harold E. Varmus

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The DNA of avian sarcoma virus assumes a closed circular configuration before integration into the host cell chromosomal DNA. Ethidium bromide reduces the formation of superhelical viral DNA and concurrently blocks integration of the viral genome. Inhibition of integration of viral DNA results in the inhibition of virus replication.

Original languageEnglish (US)
Pages (from-to)507-511
Number of pages5
JournalNature
Volume253
Issue number5492
DOIs
StatePublished - Dec 1 1975
Externally publishedYes

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Avian Sarcoma Viruses
Virus Integration
Circular DNA
DNA Viruses
Ethidium
Ducks
Viral DNA
Superhelical DNA
Viral Genome
DNA
Virus Replication

All Science Journal Classification (ASJC) codes

  • General

Cite this

Ethidium bromide inhibits appearance of closed circular viral DNA and integration of virus-specific DNA in duck cells infected by avian sarcoma virus. / Guntaka, Ramareddy; Mahy, Brian W.J.; Bishop, J. Michael; Varmus, Harold E.

In: Nature, Vol. 253, No. 5492, 01.12.1975, p. 507-511.

Research output: Contribution to journalArticle

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