Etiology of Human Genetic Disease on the Fly

Clement Y. Chow, Lawrence Reiter

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The model organism Drosophila melanogaster has been at the forefront of genetic studies since before the discovery of DNA. Although human disease modeling in flies may still be rather novel, recent advances in genetic tool design and genome sequencing now confer huge advantages in the fly system when modeling human disease. In this review, we focus on new genomic tools for human gene variant analysis; new uses for the Drosophila Genetic Reference Panel (DGRP) in detection of background alleles that influence a phenotype; and several examples of how multigenic conditions, both complex disorders and duplication and/or deletion syndromes, can be effectively studied in the fly model system. Fruit flies are a far cry from the quaint genetic model of the past, but rather, continue to evolve as a powerful system for the study of human genetic disease.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalTrends in Genetics
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2017

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Inborn Genetic Diseases
Medical Genetics
Diptera
Genetic Models
Drosophila melanogaster
Drosophila
Fruit
Alleles
Genome
Phenotype
DNA
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Etiology of Human Genetic Disease on the Fly. / Chow, Clement Y.; Reiter, Lawrence.

In: Trends in Genetics, Vol. 33, No. 6, 01.06.2017, p. 391-398.

Research output: Contribution to journalReview article

Chow, Clement Y. ; Reiter, Lawrence. / Etiology of Human Genetic Disease on the Fly. In: Trends in Genetics. 2017 ; Vol. 33, No. 6. pp. 391-398.
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