Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery

Jack Chavez, Jeffrey S. Weatherall, Stephen M. Strevels, Fengqi Liu, Carolyn C. Snider, Roger C. Carroll

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Study Objective: To evaluate a point-of-care (POC) coagulation monitoring analyzer (CoaguChek™ Pro DM) in patients undergoing cardiopulmonary bypass (CPB). Design: Prospective, blinded study. Setting: University hospital. Participants: 32 patients scheduled for elective cardiac surgery with CPB. Intervention: Arterial blood samples were drawn four times: preoperatively, postinduction, and 10 minutes and 60 minutes after reversal of heparin with protamine. Measurements and Main Results: Activated partial thromboplastin time (aPTT) and prothrombin time (PT) were measured with a point-of-care system - CoaguChek™ Pro DM as well as with the Core Laboratory facility using a MD180 analyzer. A total of 128 consecutive paired analyses were conducted. There was very good agreement of the point-of-care-based monitoring of aPTT and PT with the Core Laboratory-based monitoring of aPTT and PT (positive correlations by linear regression analysis: r2 = 0.83 and 0.92, respectively). The turn-around time (time from blood sampling until availability of data for the anesthesiologists) was significantly shorter for the point-of-care system (averaging < 10 min) than for the Core Laboratory system (averaging > 30 min). Conclusion: CoaguChek™ Pro DM is a reliable and time-efficient point-of-care system for monitoring coagulation of patients undergoing CPB. The use of this system may improve patient care in this group through timely and accurate clinical decisions.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Clinical Anesthesia
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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Point-of-Care Systems
Cardiopulmonary Bypass
Partial Thromboplastin Time
Prothrombin Time
Protamines
Physiologic Monitoring
Thoracic Surgery
Heparin
Linear Models
Patient Care
Regression Analysis
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery. / Chavez, Jack; Weatherall, Jeffrey S.; Strevels, Stephen M.; Liu, Fengqi; Snider, Carolyn C.; Carroll, Roger C.

In: Journal of Clinical Anesthesia, Vol. 16, No. 1, 01.01.2004, p. 7-10.

Research output: Contribution to journalArticle

Chavez, Jack ; Weatherall, Jeffrey S. ; Strevels, Stephen M. ; Liu, Fengqi ; Snider, Carolyn C. ; Carroll, Roger C. / Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery. In: Journal of Clinical Anesthesia. 2004 ; Vol. 16, No. 1. pp. 7-10.
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