Evaluation of adrenal function in long standing pulmonary tuberculosis: A study of 100 cases

Sameen Siddiqi, Hafiz Elahi, Mohammed Hussain, Dilshad Ahmed Khan, N. J. Beeching

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tuberculosis is a major public health problem in Pakistan and adrenal involvement in long-standing tuberculosis has been found to be common. A multi-center study was conducted to assess the adrenal function using short Synacthen® test in one hundred patients with tuberculosis of more than 6 months duration at three hospitals of Rawalpindi and Islamabad. Forty patients demonstrated impaired response to Synacthen® test. In 21 (52.5%) the increment from basal level was less than 300 nmol/L with a peak level increasing to over 600mmol//L in 15 (37.5%) patients, the increment from basal level was less than 300 nmol/L as well as the peak level was also less than 600 nmol/L. In 4 (10%) patients the increment was more than 300 nmol/L but they were not able to obtain a peak level of 600 nmol/L. No significant difference was found between the patients with normal response and the impaired response with regards to their clinical features, duration of illness, body mass index (BMI), blood pressure variation and routine biochemical profile. It is concluded that adrenal dysfunction is common in patients with long-standing tuberculosis. Diagnosis of hypoadrenalism is not possible on clinical grounds and routine biochemical examinations. Synacthen® stimulation test is necessary for its diagnosis.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume47
Issue number5
StatePublished - Dec 1 1997

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Pulmonary Tuberculosis
Tuberculosis
Adrenal Insufficiency
Pakistan
Body Mass Index
Public Health
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Evaluation of adrenal function in long standing pulmonary tuberculosis : A study of 100 cases. / Siddiqi, Sameen; Elahi, Hafiz; Hussain, Mohammed; Khan, Dilshad Ahmed; Beeching, N. J.

In: Journal of the Pakistan Medical Association, Vol. 47, No. 5, 01.12.1997, p. 132-134.

Research output: Contribution to journalArticle

Siddiqi, Sameen ; Elahi, Hafiz ; Hussain, Mohammed ; Khan, Dilshad Ahmed ; Beeching, N. J. / Evaluation of adrenal function in long standing pulmonary tuberculosis : A study of 100 cases. In: Journal of the Pakistan Medical Association. 1997 ; Vol. 47, No. 5. pp. 132-134.
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