Evaluation of host tissue integration, revascularization, and cellular infiltration within various dermal substrates

Anthony E. Capito, Sunil S. Tholpady, Hitesh Agrawal, David B. Drake, Adam J. Katz

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Acellular dermal matrices are used in a variety of reconstructive and cosmetic procedures. There seems to be host tissue integration, revascularization, and recellularization into these products, but the exact timing and differences among these remain unknown. The purpose of this study is to determine and compare these properties of 4 different acellular dermal matrices (AlloDerm, DermACELL, DermaMatrix, and Integra) in an in vivo rat model. Tissue specimens were obtained at various time points. Histology and immunohistologic assays were used to quantify the extent of cellular infiltration and revascularization within the various matrices. A bimodal cellular response was observed in all products except for DermACELL. Cellular infiltration was highest in DermACELL and lowest in AlloDerm, and angiogenesis was evident by day 7. There were clear differences within the various products. It is undetermined whether these differences are advantageous or clinically significant. Future work is needed to define the specific roles for each.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalAnnals of plastic surgery
Volume68
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Acellular Dermis
Skin
Cosmetics
Histology
Alloderm

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Evaluation of host tissue integration, revascularization, and cellular infiltration within various dermal substrates. / Capito, Anthony E.; Tholpady, Sunil S.; Agrawal, Hitesh; Drake, David B.; Katz, Adam J.

In: Annals of plastic surgery, Vol. 68, No. 5, 01.05.2012, p. 495-500.

Research output: Contribution to journalArticle

Capito, Anthony E. ; Tholpady, Sunil S. ; Agrawal, Hitesh ; Drake, David B. ; Katz, Adam J. / Evaluation of host tissue integration, revascularization, and cellular infiltration within various dermal substrates. In: Annals of plastic surgery. 2012 ; Vol. 68, No. 5. pp. 495-500.
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