Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee

Christopher B. Weldon, Arin L. Madenci, Gregory M. Tiao, Stephen P. Dunn, Max Langham, Eugene D. McGahren, Sarangarajan Ranganathan, Dolores H. López-Terrada, Milton J. Finegold, Marcio H. Malogolowkin, Jin Piao, Li Huang, Mark D. Krailo, Rebecka L. Meyers, Howard M. Katzenstein

Research output: Contribution to journalArticle

Abstract

Background: The histopathological assessment of pediatric liver tumors at presentation is critical to establish a diagnosis, guide treatment, and collect appropriate research samples. The purpose of this study was to evaluate complications associated with different approaches to liver biopsy for newly diagnosed hepatoblastoma. Methods: Children with hepatoblastoma were enrolled on Children's Oncology Group study AHEP0731 (September 2009–March 2012). This analysis evaluated the study cohort of initially unresectable patients who therefore underwent a biopsy procedure at diagnosis. The primary endpoint was clinically significant postbiopsy hemorrhage, defined as requiring red blood cell transfusion. Results: We identified 121 children who underwent open (n = 76, 63%), laparoscopic (n = 17, 14%), or percutaneous (n = 28, 23%) liver biopsies. All biopsy procedures yielded adequate tissue for diagnosis. Postbiopsy hemorrhage requiring transfusion occurred after 26% (n = 31) of biopsies. Need for blood product transfusion most frequently occurred following open (n = 27/76, 36%) and laparoscopic (n = 4/17, 24%) biopsies, compared with percutaneous (n = 0/28, 0%) biopsies (p < 0.01). Conclusions: Pretreatment biopsy of pediatric liver tumors via a percutaneous approach yielded the lowest frequency of clinically significant hemorrhage requiring transfusion, without evidence of sacrificing diagnostic accuracy. Level of Evidence: Level I.

Original languageEnglish (US)
JournalJournal of pediatric surgery
DOIs
StatePublished - Jan 1 2019

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Hepatoblastoma
Biopsy
Liver
Neoplasms
Hemorrhage
Pediatrics
Erythrocyte Transfusion
Blood Transfusion
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Evaluation of the diagnostic biopsy approach for children with hepatoblastoma : A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee. / Weldon, Christopher B.; Madenci, Arin L.; Tiao, Gregory M.; Dunn, Stephen P.; Langham, Max; McGahren, Eugene D.; Ranganathan, Sarangarajan; López-Terrada, Dolores H.; Finegold, Milton J.; Malogolowkin, Marcio H.; Piao, Jin; Huang, Li; Krailo, Mark D.; Meyers, Rebecka L.; Katzenstein, Howard M.

In: Journal of pediatric surgery, 01.01.2019.

Research output: Contribution to journalArticle

Weldon, CB, Madenci, AL, Tiao, GM, Dunn, SP, Langham, M, McGahren, ED, Ranganathan, S, López-Terrada, DH, Finegold, MJ, Malogolowkin, MH, Piao, J, Huang, L, Krailo, MD, Meyers, RL & Katzenstein, HM 2019, 'Evaluation of the diagnostic biopsy approach for children with hepatoblastoma: A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee', Journal of pediatric surgery. https://doi.org/10.1016/j.jpedsurg.2019.05.004
Weldon, Christopher B. ; Madenci, Arin L. ; Tiao, Gregory M. ; Dunn, Stephen P. ; Langham, Max ; McGahren, Eugene D. ; Ranganathan, Sarangarajan ; López-Terrada, Dolores H. ; Finegold, Milton J. ; Malogolowkin, Marcio H. ; Piao, Jin ; Huang, Li ; Krailo, Mark D. ; Meyers, Rebecka L. ; Katzenstein, Howard M. / Evaluation of the diagnostic biopsy approach for children with hepatoblastoma : A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee. In: Journal of pediatric surgery. 2019.
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abstract = "Background: The histopathological assessment of pediatric liver tumors at presentation is critical to establish a diagnosis, guide treatment, and collect appropriate research samples. The purpose of this study was to evaluate complications associated with different approaches to liver biopsy for newly diagnosed hepatoblastoma. Methods: Children with hepatoblastoma were enrolled on Children's Oncology Group study AHEP0731 (September 2009–March 2012). This analysis evaluated the study cohort of initially unresectable patients who therefore underwent a biopsy procedure at diagnosis. The primary endpoint was clinically significant postbiopsy hemorrhage, defined as requiring red blood cell transfusion. Results: We identified 121 children who underwent open (n = 76, 63{\%}), laparoscopic (n = 17, 14{\%}), or percutaneous (n = 28, 23{\%}) liver biopsies. All biopsy procedures yielded adequate tissue for diagnosis. Postbiopsy hemorrhage requiring transfusion occurred after 26{\%} (n = 31) of biopsies. Need for blood product transfusion most frequently occurred following open (n = 27/76, 36{\%}) and laparoscopic (n = 4/17, 24{\%}) biopsies, compared with percutaneous (n = 0/28, 0{\%}) biopsies (p < 0.01). Conclusions: Pretreatment biopsy of pediatric liver tumors via a percutaneous approach yielded the lowest frequency of clinically significant hemorrhage requiring transfusion, without evidence of sacrificing diagnostic accuracy. Level of Evidence: Level I.",
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T2 - A report from the Children's Oncology Group AHEP 0731 Liver Tumor Committee

AU - Weldon, Christopher B.

AU - Madenci, Arin L.

AU - Tiao, Gregory M.

AU - Dunn, Stephen P.

AU - Langham, Max

AU - McGahren, Eugene D.

AU - Ranganathan, Sarangarajan

AU - López-Terrada, Dolores H.

AU - Finegold, Milton J.

AU - Malogolowkin, Marcio H.

AU - Piao, Jin

AU - Huang, Li

AU - Krailo, Mark D.

AU - Meyers, Rebecka L.

AU - Katzenstein, Howard M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The histopathological assessment of pediatric liver tumors at presentation is critical to establish a diagnosis, guide treatment, and collect appropriate research samples. The purpose of this study was to evaluate complications associated with different approaches to liver biopsy for newly diagnosed hepatoblastoma. Methods: Children with hepatoblastoma were enrolled on Children's Oncology Group study AHEP0731 (September 2009–March 2012). This analysis evaluated the study cohort of initially unresectable patients who therefore underwent a biopsy procedure at diagnosis. The primary endpoint was clinically significant postbiopsy hemorrhage, defined as requiring red blood cell transfusion. Results: We identified 121 children who underwent open (n = 76, 63%), laparoscopic (n = 17, 14%), or percutaneous (n = 28, 23%) liver biopsies. All biopsy procedures yielded adequate tissue for diagnosis. Postbiopsy hemorrhage requiring transfusion occurred after 26% (n = 31) of biopsies. Need for blood product transfusion most frequently occurred following open (n = 27/76, 36%) and laparoscopic (n = 4/17, 24%) biopsies, compared with percutaneous (n = 0/28, 0%) biopsies (p < 0.01). Conclusions: Pretreatment biopsy of pediatric liver tumors via a percutaneous approach yielded the lowest frequency of clinically significant hemorrhage requiring transfusion, without evidence of sacrificing diagnostic accuracy. Level of Evidence: Level I.

AB - Background: The histopathological assessment of pediatric liver tumors at presentation is critical to establish a diagnosis, guide treatment, and collect appropriate research samples. The purpose of this study was to evaluate complications associated with different approaches to liver biopsy for newly diagnosed hepatoblastoma. Methods: Children with hepatoblastoma were enrolled on Children's Oncology Group study AHEP0731 (September 2009–March 2012). This analysis evaluated the study cohort of initially unresectable patients who therefore underwent a biopsy procedure at diagnosis. The primary endpoint was clinically significant postbiopsy hemorrhage, defined as requiring red blood cell transfusion. Results: We identified 121 children who underwent open (n = 76, 63%), laparoscopic (n = 17, 14%), or percutaneous (n = 28, 23%) liver biopsies. All biopsy procedures yielded adequate tissue for diagnosis. Postbiopsy hemorrhage requiring transfusion occurred after 26% (n = 31) of biopsies. Need for blood product transfusion most frequently occurred following open (n = 27/76, 36%) and laparoscopic (n = 4/17, 24%) biopsies, compared with percutaneous (n = 0/28, 0%) biopsies (p < 0.01). Conclusions: Pretreatment biopsy of pediatric liver tumors via a percutaneous approach yielded the lowest frequency of clinically significant hemorrhage requiring transfusion, without evidence of sacrificing diagnostic accuracy. Level of Evidence: Level I.

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