Evaluation of the optical isomers of tetrahydroisoquinolines in rat adipose tissue and guinea pig aorta

Ock Soon Lee, Janice A. Mears, Duane Miller, Dennis R. Feller

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The adrenoceptive properties of tetrahydroisoquinoline (THI) stereoisomers were evaluated in rat adipose tissue and guinea pig aorta, in vitro. The rank order of lipolytic activity observed for the more potent S-(-)-isomers of the THI's tested was trimetoquinol > 1-benzyl-6,7-dihydroxy-1,2,3,4-THI > tetrahydropapaveroline > salsolinol. The stereoisomers of trimetoquinol and racemic 1-benzyl-6,7-dihydroxy-1,2,3,4-THI were found to be equally active as competitive antagonists of noradrenaline-induced contraction of guinea pig aortic strips.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalEuropean Journal of Pharmacology
Volume28
Issue number1
DOIs
StatePublished - Jan 1 1974

Fingerprint

Tretoquinol
Tetrahydroisoquinolines
Stereoisomerism
Aorta
Tetrahydropapaveroline
Adipose Tissue
Guinea Pigs
Norepinephrine
1-benzyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Evaluation of the optical isomers of tetrahydroisoquinolines in rat adipose tissue and guinea pig aorta. / Lee, Ock Soon; Mears, Janice A.; Miller, Duane; Feller, Dennis R.

In: European Journal of Pharmacology, Vol. 28, No. 1, 01.01.1974, p. 225-229.

Research output: Contribution to journalArticle

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