Evaluation of the prognosis of in vitro fertilization pregnancies with initially low serum human chorionic gonadotropin levels

Gary N. Frishman, Richard J. Hackett, Margaret McGrath, William Metheny

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: The objective of this study was to investigate the prognostic significance of initially low serum early human chorionic gonadotropin levels in in vitro fertilization pregnancies that progress to an intrauterine gestational sac. STUDY DESIGN: This retrospective cohort study compared 65 in vitro fertilization pregnancies with an initial human chorionic gonadotropin value at 4 weeks of ≤20 mlU/mL with 130 pregnancies with human chorionic gonadotropin values >20 mlU/mL. All pregnancies had a singleton intrauterine sac at 6 weeks' gestational age. Spontaneous abortion rates and pregnancy complications were compared. RESULTS: Women with a low initial serum human chorionic gonadotropin level showed a statistically significant increase in first-trimester pregnancy loss (36.5% vs 9.2%; odds ratio, 5.7; 95%; confidence interval, 2.6, 12.4; P <. 0001). Once pregnancies progressed to 13 weeks, there were no significant differences. CONCLUSIONS: In vitro fertilization pregnancies with a low initial human chorionic gonadotropin value, despite progressing to a gestational sac, are at an increased risk of spontaneous abortion.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume185
Issue number2
DOIs
StatePublished - Jan 1 2001

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Chorionic Gonadotropin
Fertilization in Vitro
Pregnancy
Serum
Gestational Sac
Spontaneous Abortion
Pregnancy Complications
Induced Abortion
First Pregnancy Trimester
Gestational Age
Cohort Studies
Retrospective Studies
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Evaluation of the prognosis of in vitro fertilization pregnancies with initially low serum human chorionic gonadotropin levels. / Frishman, Gary N.; Hackett, Richard J.; McGrath, Margaret; Metheny, William.

In: American Journal of Obstetrics and Gynecology, Vol. 185, No. 2, 01.01.2001, p. 392-395.

Research output: Contribution to journalArticle

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N2 - OBJECTIVE: The objective of this study was to investigate the prognostic significance of initially low serum early human chorionic gonadotropin levels in in vitro fertilization pregnancies that progress to an intrauterine gestational sac. STUDY DESIGN: This retrospective cohort study compared 65 in vitro fertilization pregnancies with an initial human chorionic gonadotropin value at 4 weeks of ≤20 mlU/mL with 130 pregnancies with human chorionic gonadotropin values >20 mlU/mL. All pregnancies had a singleton intrauterine sac at 6 weeks' gestational age. Spontaneous abortion rates and pregnancy complications were compared. RESULTS: Women with a low initial serum human chorionic gonadotropin level showed a statistically significant increase in first-trimester pregnancy loss (36.5% vs 9.2%; odds ratio, 5.7; 95%; confidence interval, 2.6, 12.4; P <. 0001). Once pregnancies progressed to 13 weeks, there were no significant differences. CONCLUSIONS: In vitro fertilization pregnancies with a low initial human chorionic gonadotropin value, despite progressing to a gestational sac, are at an increased risk of spontaneous abortion.

AB - OBJECTIVE: The objective of this study was to investigate the prognostic significance of initially low serum early human chorionic gonadotropin levels in in vitro fertilization pregnancies that progress to an intrauterine gestational sac. STUDY DESIGN: This retrospective cohort study compared 65 in vitro fertilization pregnancies with an initial human chorionic gonadotropin value at 4 weeks of ≤20 mlU/mL with 130 pregnancies with human chorionic gonadotropin values >20 mlU/mL. All pregnancies had a singleton intrauterine sac at 6 weeks' gestational age. Spontaneous abortion rates and pregnancy complications were compared. RESULTS: Women with a low initial serum human chorionic gonadotropin level showed a statistically significant increase in first-trimester pregnancy loss (36.5% vs 9.2%; odds ratio, 5.7; 95%; confidence interval, 2.6, 12.4; P <. 0001). Once pregnancies progressed to 13 weeks, there were no significant differences. CONCLUSIONS: In vitro fertilization pregnancies with a low initial human chorionic gonadotropin value, despite progressing to a gestational sac, are at an increased risk of spontaneous abortion.

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