Evidence for a bone-kidney axis regulating phosphate homeostasis

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

A novel circulation phosphaturic hormone is postulated to regulate systemic phosphate homeostasis. Two new studies (see the related articles beginning on pages 683 and 785) reveal that the phosphaturic factor FGF-23 is increased in hypophosphatemic subjects with McCune-Albright syndrome and that secreted frizzled-related protein-4 (sFRP-4), a factor produced by tumors derived from subjects with tumor-induced osteomalacia, also has phosphaturic activity. It remains to be established whether FGF-23 and sFRP-4 represent two distinct phosphatonins or are somehow integrated in a novel phosphate-regulating bone-kidney axis.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalJournal of Clinical Investigation
Volume112
Issue number5
DOIs
StatePublished - Sep 1 2003

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Homeostasis
Phosphates
Polyostotic Fibrous Dysplasia
Kidney
Bone and Bones
Hormones
Neoplasms
rat Sfrp4 protein
Oncogenic osteomalacia

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Evidence for a bone-kidney axis regulating phosphate homeostasis. / Quarles, Leigh.

In: Journal of Clinical Investigation, Vol. 112, No. 5, 01.09.2003, p. 642-646.

Research output: Contribution to journalReview article

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