Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis

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Abstract

Peripheral blood leukocytes from 12 patients with progressive systemic sclerosis and from 12 normal subjects were cultured in the presence of human skin collagen, lathryritic chick skin collagen, and α-chains from chick skin collagen. Leukocytes from 11 of the patients produced a factor chemotactic for human monocytes when cultured with the collagen preparations. The one patient whose cells did not respond to the collagen preparations also failed to respond to other common antigens and was apparently anergic. In addition, lymphocytes from three of the patients were found to transform when cultured with the collagen preparations. These responses were significantly different from the response of leukocytes from normal control subjects. The data suggest that patients with progressive systemic sclerosis may have cellular immunity to collagen.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume88
Issue number4
StatePublished - Jan 1 1976

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Diffuse Scleroderma
Cellular Immunity
Collagen
Skin
Leukocytes
Lymphocytes
Chemotactic Factors
Monocytes
Blood
Antigens

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis. / Stuart, John; Postlethwaite, Arnold; Kang, Andrew.

In: The Journal of Laboratory and Clinical Medicine, Vol. 88, No. 4, 01.01.1976, p. 601-607.

Research output: Contribution to journalArticle

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