Evidence for increased calcium influx across the choroid plexus following brief ischemia of gerbil brain

Junichi Ikeda, Günter Mies, Thaddeus Nowak, Ferenc Joó, Igor Klatzo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Following 5 min ischemia of gerbil brain, unidirectional transfer of calcium from plasma to cerebrospinal fluid was measured quantitatively with 45CaCl2 at 4 days postischemic recirculation. 45Ca influx across the choroid plexus increased significantly from 0.0101 ±0.001 min-1 measured in sham-operated animals (n=15) to 0.0294±0.002 min-1 determined in ischemic animals (n=21; P<0.05). Histological examination of choroid plexus was carried out in Cresyl violet-stained sections from gerbils subjected to 5 min ischemia followed by 4 days (n=6) and 7 days (n=7) postischemic recirculation. Increased calcium transfer to cerebrospinal fluid was associated with cell damage of choroid plexus observed at 4 days postischemia. Endothelial choroid plexus injury was still detectable at 7 days after the ischemic insult suggesting a long-lasting pathomorphological process. Postischemic alterations in choroid plexus functions apparently expose brain tissue to much higher calcium influx into cerebrospinal fluid which, in turn, may contribute to calcium-related cell damage of the central nervous system.

Original languageEnglish (US)
Pages (from-to)257-259
Number of pages3
JournalNeuroscience Letters
Volume142
Issue number2
DOIs
StatePublished - Aug 17 1992

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Choroid Plexus
Gerbillinae
Brain Ischemia
Calcium
Cerebrospinal Fluid
Ischemia
Central Nervous System
Wounds and Injuries
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Evidence for increased calcium influx across the choroid plexus following brief ischemia of gerbil brain. / Ikeda, Junichi; Mies, Günter; Nowak, Thaddeus; Joó, Ferenc; Klatzo, Igor.

In: Neuroscience Letters, Vol. 142, No. 2, 17.08.1992, p. 257-259.

Research output: Contribution to journalArticle

Ikeda, Junichi ; Mies, Günter ; Nowak, Thaddeus ; Joó, Ferenc ; Klatzo, Igor. / Evidence for increased calcium influx across the choroid plexus following brief ischemia of gerbil brain. In: Neuroscience Letters. 1992 ; Vol. 142, No. 2. pp. 257-259.
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