Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus

Virender K. Sharma, Saba E. Demian, Donald Taillon, Rajeev Vasudeva, Colin Howden

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

H. pylori may colonize columnar-lined esophagus, although an etiologic role in esophageal adenocarcinoma is unproven. H. pylori can adhere to intestinal metaplasia in the stomach. This study was designed to examine if H. pylori adheres to specialized intestinal metaplasia in columnar-lined esophagus. Esophageal biopsies from patients with columnar-lined esophagus were reviewed. Patients with only gastric metaplasia were excluded. Sections with specialized intestinal metaplasia in at least one third of at least one gland were recut, stained using the Giemsa stain, and reexamined by two independent pathologists using strict criteria for adherence by H. pylori. The 209 esophageal biopsies with adequate specialized intestinal metaplasia from 58 patients were examined: H. pylori was only seen on gastric metaplasia in three patients - and never on specialized intestinal metaplasia. Within the esophagus, H. pylori adheres only to gastric metaplasia, which is not considered premalignant for esophageal adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)1165-1168
Number of pages4
JournalDigestive Diseases and Sciences
Volume44
Issue number6
DOIs
StatePublished - Jul 8 1999

Fingerprint

Metaplasia
Tissue Distribution
Helicobacter pylori
Esophagus
Stomach
Adenocarcinoma
Azure Stains
Biopsy

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus. / Sharma, Virender K.; Demian, Saba E.; Taillon, Donald; Vasudeva, Rajeev; Howden, Colin.

In: Digestive Diseases and Sciences, Vol. 44, No. 6, 08.07.1999, p. 1165-1168.

Research output: Contribution to journalArticle

Sharma, Virender K. ; Demian, Saba E. ; Taillon, Donald ; Vasudeva, Rajeev ; Howden, Colin. / Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus. In: Digestive Diseases and Sciences. 1999 ; Vol. 44, No. 6. pp. 1165-1168.
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