Excellent Local Control Rates and Distinctive Patterns of Failure in Myxoid Liposarcoma Treated With Conservation Surgery and Radiotherapy

B. Ashleigh Guadagnolo, Gunar K. Zagars, Matthew Ballo, Shreyaskumar R. Patel, Valerae O. Lewis, Robert S. Benjamin, Raphael E. Pollock

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Purpose: To evaluate the local control rates and patterns of metastatic relapse in patients with localized myxoid liposarcoma treated with conservation surgery and radiotherapy (RT). Patients and Methods: Between 1960 and 2003, 127 patients with non-metastatic myxoid liposarcoma were treated with conservation surgery and RT at our institution. The median patient age was 39 years (range, 14-79 years). Of the 127 patients, 46% underwent preoperative RT (median dose, 50 Gy) and 54% underwent postoperative RT (median dose, 60 Gy). Also, 28% received doxorubicin-based chemotherapy as a part of their treatment. Results: The median follow-up was 9.1 years. The overall survival rate at 5 and 10 years was 87% and 79%, respectively. The corresponding disease-free survival rates were 81% and 73%. The local control rate at ≥5 years was 97%. The actuarial rate of distant metastases at 5 and 10 years was 15% and 24%, respectively. Of the 27 patients who developed distant metastases, 48% did so in the retroperitoneum, 22% in other extrapulmonary soft tissues, 22% in the lung, 15% in bone, and 4% in the liver. Conclusion: The results of our study have shown that RT and conservation surgery for localized myxoid liposarcoma provide excellent local control. Distant metastatic relapse tended to occur in the retroperitoneum and other nonpulmonary soft tissues. Therefore, staging and surveillance imaging should include the abdomen and pelvis, as well as the thorax, for patients with localized myxoid liposarcoma.

Original languageEnglish (US)
Pages (from-to)760-765
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume70
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

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Myxoid Liposarcoma
surgery
conservation
radiation therapy
Radiotherapy
metastasis
Survival Rate
Neoplasm Metastasis
thorax
Recurrence
abdomen
dosage
pelvis
chemotherapy
surveillance
Pelvis
liver
Abdomen
Doxorubicin
lungs

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Excellent Local Control Rates and Distinctive Patterns of Failure in Myxoid Liposarcoma Treated With Conservation Surgery and Radiotherapy. / Guadagnolo, B. Ashleigh; Zagars, Gunar K.; Ballo, Matthew; Patel, Shreyaskumar R.; Lewis, Valerae O.; Benjamin, Robert S.; Pollock, Raphael E.

In: International Journal of Radiation Oncology Biology Physics, Vol. 70, No. 3, 01.03.2008, p. 760-765.

Research output: Contribution to journalArticle

Guadagnolo, B. Ashleigh ; Zagars, Gunar K. ; Ballo, Matthew ; Patel, Shreyaskumar R. ; Lewis, Valerae O. ; Benjamin, Robert S. ; Pollock, Raphael E. / Excellent Local Control Rates and Distinctive Patterns of Failure in Myxoid Liposarcoma Treated With Conservation Surgery and Radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2008 ; Vol. 70, No. 3. pp. 760-765.
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abstract = "Purpose: To evaluate the local control rates and patterns of metastatic relapse in patients with localized myxoid liposarcoma treated with conservation surgery and radiotherapy (RT). Patients and Methods: Between 1960 and 2003, 127 patients with non-metastatic myxoid liposarcoma were treated with conservation surgery and RT at our institution. The median patient age was 39 years (range, 14-79 years). Of the 127 patients, 46{\%} underwent preoperative RT (median dose, 50 Gy) and 54{\%} underwent postoperative RT (median dose, 60 Gy). Also, 28{\%} received doxorubicin-based chemotherapy as a part of their treatment. Results: The median follow-up was 9.1 years. The overall survival rate at 5 and 10 years was 87{\%} and 79{\%}, respectively. The corresponding disease-free survival rates were 81{\%} and 73{\%}. The local control rate at ≥5 years was 97{\%}. The actuarial rate of distant metastases at 5 and 10 years was 15{\%} and 24{\%}, respectively. Of the 27 patients who developed distant metastases, 48{\%} did so in the retroperitoneum, 22{\%} in other extrapulmonary soft tissues, 22{\%} in the lung, 15{\%} in bone, and 4{\%} in the liver. Conclusion: The results of our study have shown that RT and conservation surgery for localized myxoid liposarcoma provide excellent local control. Distant metastatic relapse tended to occur in the retroperitoneum and other nonpulmonary soft tissues. Therefore, staging and surveillance imaging should include the abdomen and pelvis, as well as the thorax, for patients with localized myxoid liposarcoma.",
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