Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse

Scott Sinclair, Steve McKinney, Robb W. Glenny, Susan L. Bernard, Michael P. Hlastala

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We determined the changes in fractal dimensions and spatial correlations of regional pulmonary blood flow with increasing exercise in race horses (n = 4) by using 15-μm fluorescent microspheres. Fluorescence was measured to quantitate regional blood to 1.3-cm3 samples (n = 1,621-2,503). Perfusion distributions were characterized with fractal dimensions (a measure of spatial variability) and spatial correlations. On average, the fractal dimension decreased with exercise (trot 1.216 to gallop 1.173; P < 0.05) despite a variable fractal dimension at rest. Spatial correlation of flow to neighboring pieces increased with exercise (trot 0.57 ± 0.074 to gallop 0.73 ± 0.051) and was inversely correlated with fractal dimension, indicating better spatial correlation as blood flow distribution becomes more uniform. This is the first study to document a change in fractal dimension as a result of increasing pulmonary blood flow. Spatial differences in response to vasoregulatory mediators may play a role in this phenomenon.

Original languageEnglish (US)
Pages (from-to)2269-2278
Number of pages10
JournalJournal of Applied Physiology
Volume88
Issue number6
StatePublished - Jul 25 2000
Externally publishedYes

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Fractals
Horses
Lung
Regional Blood Flow
Microspheres
Perfusion
Fluorescence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Sinclair, S., McKinney, S., Glenny, R. W., Bernard, S. L., & Hlastala, M. P. (2000). Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse. Journal of Applied Physiology, 88(6), 2269-2278.

Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse. / Sinclair, Scott; McKinney, Steve; Glenny, Robb W.; Bernard, Susan L.; Hlastala, Michael P.

In: Journal of Applied Physiology, Vol. 88, No. 6, 25.07.2000, p. 2269-2278.

Research output: Contribution to journalArticle

Sinclair, S, McKinney, S, Glenny, RW, Bernard, SL & Hlastala, MP 2000, 'Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse', Journal of Applied Physiology, vol. 88, no. 6, pp. 2269-2278.
Sinclair, Scott ; McKinney, Steve ; Glenny, Robb W. ; Bernard, Susan L. ; Hlastala, Michael P. / Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse. In: Journal of Applied Physiology. 2000 ; Vol. 88, No. 6. pp. 2269-2278.
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