Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity

Sarah J. Lessard, Donato A. Rivas, Erin Stephenson, Ben B. Yaspelkis, Lauren G. Koch, Steven L. Britton, John A. Hawley

Research output: Contribution to journalArticle

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Abstract

We have used a novel model of genetically imparted endurance exercise capacity and metabolic health to study the genetic and environmental contributions to skeletal muscle glucose and lipid metabolism. We hypothesized that metabolic abnormalities associated with low intrinsic running capacity would be ameliorated by exercise training. Selective breeding for 22 generations resulted in rat models with a fivefold difference in intrinsic aerobic capacity. Low (LCR)- and high (HCR)-capacity runners remained sedentary (SED) or underwent 6 wk of exercise training (EXT). Insulin-stimulated glucose transport, insulin signal transduction, and rates of palmitate oxidation were lower in LCR SED vs. HCR SED (P < 0.05). Decreases in glucose and lipid metabolism were associated with decreased β2-adrenergic receptor (β2-AR), and reduced expression of Nur77 target proteins that are critical regulators of muscle glucose and lipid metabolism [uncoupling protein-3 (UCP3), fatty acid transporter (FAT)/CD36; P < 0.01 and P < 0.05, respectively]. EXT reversed the impairments to glucose and lipid metabolism observed in the skeletal muscle of LCR, while increasing the expression of β2-AR, Nur77, GLUT4, UCP3, and FAT/CD36 (P < 0.05) in this tissue. However, no metabolic improvements were observed following exercise training in HCR. Our results demonstrate that metabolic impairments resulting from genetic factors (low intrinsic aerobic capacity) can be overcome by an environmental intervention (exercise training). Furthermore, we identify Nur77 as a potential mechanism for improved skeletal muscle metabolism in response to EXT.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume300
Issue number1
DOIs
StatePublished - Jan 1 2011

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Skeletal Muscle
Exercise
Lipid Metabolism
Glucose
CD36 Antigens
Adrenergic Receptors
Glucose Transporter Type 4
Insulin
Intrinsic Factor
Palmitates
Running
Signal Transduction
Muscles
Health
Proteins
Uncoupling Protein 3

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. / Lessard, Sarah J.; Rivas, Donato A.; Stephenson, Erin; Yaspelkis, Ben B.; Koch, Lauren G.; Britton, Steven L.; Hawley, John A.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 300, No. 1, 01.01.2011.

Research output: Contribution to journalArticle

Lessard, Sarah J. ; Rivas, Donato A. ; Stephenson, Erin ; Yaspelkis, Ben B. ; Koch, Lauren G. ; Britton, Steven L. ; Hawley, John A. / Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2011 ; Vol. 300, No. 1.
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