Expeditious amide-forming reactions using thiol esters

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The reaction of a 2-pyridylthiol ester with a dimethylaluminum amide leads to the rapid formation of the corresponding amide. The tolylthiol esters can be activated with silver trifluoroacetate and coupled even with poorly reactive amino compounds. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number5
DOIs
StatePublished - Jan 29 2000
Externally publishedYes

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Sulfhydryl Compounds
Amides
Esters
Trifluoroacetic Acid
Silver

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Expeditious amide-forming reactions using thiol esters. / Kurosu, Michio.

In: Tetrahedron Letters, Vol. 41, No. 5, 29.01.2000, p. 591-594.

Research output: Contribution to journalArticle

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abstract = "The reaction of a 2-pyridylthiol ester with a dimethylaluminum amide leads to the rapid formation of the corresponding amide. The tolylthiol esters can be activated with silver trifluoroacetate and coupled even with poorly reactive amino compounds. (C) 2000 Elsevier Science Ltd.",
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