Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex

Hongwei Dong, Quanxin Wang, Katia Valkova, Yuri Gonchar, Andreas Burkhalter

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.

Original languageEnglish (US)
Pages (from-to)3389-3400
Number of pages12
JournalVision Research
Volume44
Issue number28 SPEC.ISS.
DOIs
StatePublished - Jan 1 2004

Fingerprint

Visual Cortex
Sutures
Inhibitory Postsynaptic Potentials
Pyramidal Cells
Excitatory Postsynaptic Potentials
Patch-Clamp Techniques
Synapses

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems

Cite this

Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex. / Dong, Hongwei; Wang, Quanxin; Valkova, Katia; Gonchar, Yuri; Burkhalter, Andreas.

In: Vision Research, Vol. 44, No. 28 SPEC.ISS., 01.01.2004, p. 3389-3400.

Research output: Contribution to journalArticle

Dong, Hongwei ; Wang, Quanxin ; Valkova, Katia ; Gonchar, Yuri ; Burkhalter, Andreas. / Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex. In: Vision Research. 2004 ; Vol. 44, No. 28 SPEC.ISS. pp. 3389-3400.
@article{89b80ad44c3a4ecd8f5e0d25db2f9a2a,
title = "Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex",
abstract = "Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.",
author = "Hongwei Dong and Quanxin Wang and Katia Valkova and Yuri Gonchar and Andreas Burkhalter",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.visres.2004.09.007",
language = "English (US)",
volume = "44",
pages = "3389--3400",
journal = "Vision Research",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "28 SPEC.ISS.",

}

TY - JOUR

T1 - Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex

AU - Dong, Hongwei

AU - Wang, Quanxin

AU - Valkova, Katia

AU - Gonchar, Yuri

AU - Burkhalter, Andreas

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.

AB - Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.

UR - http://www.scopus.com/inward/record.url?scp=7944229938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7944229938&partnerID=8YFLogxK

U2 - 10.1016/j.visres.2004.09.007

DO - 10.1016/j.visres.2004.09.007

M3 - Article

VL - 44

SP - 3389

EP - 3400

JO - Vision Research

JF - Vision Research

SN - 0042-6989

IS - 28 SPEC.ISS.

ER -