Experimental and Outcome-Based Approaches to Protein Requirements in the Intensive Care Unit

Peter J.M. Weijs, Roland Dickerson, Daren K. Heyland, Frederick A. Moore, Saúl J. Rugeles, Stephen A. McClave

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Insight into protein requirements of intensive care unit (ICU) patients is urgently needed, but at present, it is unrealistic to define protein requirements for different diagnostic groups of critical illness or at different stages of illness. No large randomized controlled trials have randomized protein delivery, adequately addressed energy intake, and evaluated relevant clinical outcomes. As a pragmatic approach, experimental studies have focused on protein requirements of heterogeneous ICU patients. Data are scarce and the absolute value of protein requirements therefore is an approximation. Experimental studies indicate a protein requirement of >1.2 g/kg protein, which is supported by several outcome-based observational studies. Protein intake levels of up to 2.0-2.5 g/kg appear to be safe. A higher level of personalized treatment, within 1.2 and 2.5 g/kg, must involve identification of patients with low muscle protein mass that might benefit most from adequate protein nutrition in the ICU.

Original languageEnglish (US)
Pages (from-to)77S-85S
JournalNutrition in Clinical Practice
Volume32
Issue number1_suppl
DOIs
StatePublished - Apr 1 2017

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Intensive Care Units
Proteins
Muscle Proteins
Energy Intake
Critical Illness
Observational Studies
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Experimental and Outcome-Based Approaches to Protein Requirements in the Intensive Care Unit. / Weijs, Peter J.M.; Dickerson, Roland; Heyland, Daren K.; Moore, Frederick A.; Rugeles, Saúl J.; McClave, Stephen A.

In: Nutrition in Clinical Practice, Vol. 32, No. 1_suppl, 01.04.2017, p. 77S-85S.

Research output: Contribution to journalArticle

Weijs, Peter J.M. ; Dickerson, Roland ; Heyland, Daren K. ; Moore, Frederick A. ; Rugeles, Saúl J. ; McClave, Stephen A. / Experimental and Outcome-Based Approaches to Protein Requirements in the Intensive Care Unit. In: Nutrition in Clinical Practice. 2017 ; Vol. 32, No. 1_suppl. pp. 77S-85S.
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