Experimental cerebral ischemia produced by extracranial vascular injury

Protection with indomethacin and prostacyclin

John Dougherty, David E. Levy, Donald G. Rawlinson, Robert Ruff, Babette B. Weksler, Fred Plum

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To determine whether the production of brain ischemia is modified by antiplatelet agents administered at the time of extracranial endothelial injury, we modified a four-vessel occlusion rat model so that an electrogenic platelet thrombus in one carotid artery produced cerebral ischemia. DC current was passed through an anode around the left carotid artery of 11 rats with preoccluded vertebral and contralateral carotid arteries. Five of six untreated rats became unresponsive because of carotid occlusion and resultant cerebral ischemia; none of five animals pretreated with indomethacin and infused with prostacyclin (PGI2) were clinically affected. Light-and electronmicroscopic studies showed arterial platelet-fibrin thrombi and ischemic brain damage in untreated rats. All rats had received radiolabeled platelets; radioactivity was increased in the electrogenically injured left carotid arteries from treated and untreated rats, but counts were reduced by more than 80% in indomethacin/ PGI2-treated rats (p < 0.01).

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalNeurology
Volume32
Issue number9
StatePublished - Jan 1 1982
Externally publishedYes

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Vascular System Injuries
Epoprostenol
Brain Ischemia
Indomethacin
Carotid Arteries
Blood Platelets
Intracranial Thrombosis
Platelet Aggregation Inhibitors
Fibrin
Radioactivity
Electrodes
Thrombosis
Light
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Dougherty, J., Levy, D. E., Rawlinson, D. G., Ruff, R., Weksler, B. B., & Plum, F. (1982). Experimental cerebral ischemia produced by extracranial vascular injury: Protection with indomethacin and prostacyclin. Neurology, 32(9), 970-974.

Experimental cerebral ischemia produced by extracranial vascular injury : Protection with indomethacin and prostacyclin. / Dougherty, John; Levy, David E.; Rawlinson, Donald G.; Ruff, Robert; Weksler, Babette B.; Plum, Fred.

In: Neurology, Vol. 32, No. 9, 01.01.1982, p. 970-974.

Research output: Contribution to journalArticle

Dougherty, J, Levy, DE, Rawlinson, DG, Ruff, R, Weksler, BB & Plum, F 1982, 'Experimental cerebral ischemia produced by extracranial vascular injury: Protection with indomethacin and prostacyclin', Neurology, vol. 32, no. 9, pp. 970-974.
Dougherty, John ; Levy, David E. ; Rawlinson, Donald G. ; Ruff, Robert ; Weksler, Babette B. ; Plum, Fred. / Experimental cerebral ischemia produced by extracranial vascular injury : Protection with indomethacin and prostacyclin. In: Neurology. 1982 ; Vol. 32, No. 9. pp. 970-974.
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