Experimental cerebral ischemia produces platelet aggregates

John Dougherty, D. E. Levy, B. B. Weksler

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Human studies indicate that transient platelet abnormalities accompany acute cerebral ischemia. Although these abnormalities may precipitate the ischemic process, ischemia could also alter platelet function. Platelets were therefore studied in gerbils subjected to 1 hour of unilateral carotid artery occlusion. Venous blood from five clinically affected gerbils contained more aggregated platelets (37.8% ± 6.4) than did blood from eight unaffected animals (11.1% ± 3.0; p <0.01). Platelets labeled with 3H-serotonin were increased in ishcemic brain; the ratio of radioactivity in the ipsilateral versus contralateral hemisphere was greater in eight dected (1.09 f 0.03) than in 19 unaffected (1.00 ± 0.01; p <0.02) animals. The radioactive serotonin was located predominantly within blood vessels. Cerebral ischemia thus stimulated the formation of platelet aggregates, a response which could contribute to the ischemic process.

Original languageEnglish (US)
Pages (from-to)1460-1465
Number of pages6
JournalNeurology
Volume29
Issue number11
StatePublished - Jan 1 1979
Externally publishedYes

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Brain Ischemia
Blood Platelets
Gerbillinae
Serotonin
Carotid Arteries
Radioactivity
Blood Vessels
Ischemia
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Dougherty, J., Levy, D. E., & Weksler, B. B. (1979). Experimental cerebral ischemia produces platelet aggregates. Neurology, 29(11), 1460-1465.

Experimental cerebral ischemia produces platelet aggregates. / Dougherty, John; Levy, D. E.; Weksler, B. B.

In: Neurology, Vol. 29, No. 11, 01.01.1979, p. 1460-1465.

Research output: Contribution to journalArticle

Dougherty, J, Levy, DE & Weksler, BB 1979, 'Experimental cerebral ischemia produces platelet aggregates', Neurology, vol. 29, no. 11, pp. 1460-1465.
Dougherty J, Levy DE, Weksler BB. Experimental cerebral ischemia produces platelet aggregates. Neurology. 1979 Jan 1;29(11):1460-1465.
Dougherty, John ; Levy, D. E. ; Weksler, B. B. / Experimental cerebral ischemia produces platelet aggregates. In: Neurology. 1979 ; Vol. 29, No. 11. pp. 1460-1465.
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