Experimental model for repetitive ischemic attacks in the gerbil

The cumulative effect of repeated ischemic insults

S. Tomida, Thaddeus Nowak, K. Vass, J. M. Lohr, I. Klatzo

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

An experimental model for repeated ischemic attacks, which allows easy induction of cerebral ischemia of any desired duration and frequency, has been developed in the gerbil. With this procedure, a pronounced cumulative effect on development of edema and tissue injury was observed using 3 separate, 5-min bilateral occlusions of the common carotid arteries spaced at various time intervals. This effect was most evident when the occlusions were carried out at 1-h intervals, i.e., during the period of marked postischemic hypoperfusion. Such animals, killed after 24 h of recirculation, showed significantly more severe edema and brain tissue injury in the areas exposed to ischemia than was observed in animals killed 24 h after single 5- or 15-min occlusions. The changes of regional CBF, assayed with a [3H]nicotine method, indicated a relatively rapid onset of hypoperfusion of similar degree after each release of arterial occlusion. The hypoperfusion recovered significantly within 6 h of recirculation following either single or multiple occlusions, and no residual hypoperfusion was observed in animals which, when killed at 24 h, showed severe edema and brain tissue injury. This model should prove useful in elucidating the pathophysiological mechanisms operative in repetitive cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)773-782
Number of pages10
JournalJournal of Cerebral Blood Flow and Metabolism
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1987

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Gerbillinae
Edema
Theoretical Models
Brain Ischemia
Brain Injuries
Common Carotid Artery
Nicotine
Ischemia
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Experimental model for repetitive ischemic attacks in the gerbil : The cumulative effect of repeated ischemic insults. / Tomida, S.; Nowak, Thaddeus; Vass, K.; Lohr, J. M.; Klatzo, I.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 7, No. 6, 01.01.1987, p. 773-782.

Research output: Contribution to journalArticle

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