Expression and regulation of carnitine palmitoyltransferase-Iα and -Iβ genes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Two genes control expression of mitochondrial carnitine palmitoyltransferase-I (CPT-I), the enzyme that catalyzes the primary rate- controlling step in fatty acid oxidation. Two CPT-I isoforms have been found - a 'liver' isoform (CPT-Iα) expressed in most tissues, but not in skeletal muscles, and a 'muscle' isoform (CPT-Iβ) expressed in muscles and adipocytes. Liver CPT-Iα increases dramatically at birth, but heart CPT-Iα is abundant in the fetus and diminishes at birth. Insulin, thyroid hormone, and fatty acids regulate expression of CPT-Iα in liver, whereas electrical stimulation increases CPT-Iβ and decreases CPT-Iα in cardiac myocytes. Both genes are TATA-less and contain Sp1 transcription factor binding sites upstream of the start site of transcription. Multiple transcripts of both CPT-Iα and CPT-Iβ exist, some of which may have roles in regulating fatty acid oxidation.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume318
Issue number1
StatePublished - Jan 1 1999

Fingerprint

Carnitine O-Palmitoyltransferase
Genes
Protein Isoforms
Fatty Acids
Liver
Parturition
Sp1 Transcription Factor
Muscles
Transcription Initiation Site
Thyroid Hormones
Adipocytes
Cardiac Myocytes
Electric Stimulation
Skeletal Muscle
Fetus
Binding Sites

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Expression and regulation of carnitine palmitoyltransferase-Iα and -Iβ genes. / Cook, George; Park, Edwards.

In: American Journal of the Medical Sciences, Vol. 318, No. 1, 01.01.1999, p. 43-48.

Research output: Contribution to journalArticle

@article{ed1e8c7556774c85832c8790bd9717f9,
title = "Expression and regulation of carnitine palmitoyltransferase-Iα and -Iβ genes",
abstract = "Two genes control expression of mitochondrial carnitine palmitoyltransferase-I (CPT-I), the enzyme that catalyzes the primary rate- controlling step in fatty acid oxidation. Two CPT-I isoforms have been found - a 'liver' isoform (CPT-Iα) expressed in most tissues, but not in skeletal muscles, and a 'muscle' isoform (CPT-Iβ) expressed in muscles and adipocytes. Liver CPT-Iα increases dramatically at birth, but heart CPT-Iα is abundant in the fetus and diminishes at birth. Insulin, thyroid hormone, and fatty acids regulate expression of CPT-Iα in liver, whereas electrical stimulation increases CPT-Iβ and decreases CPT-Iα in cardiac myocytes. Both genes are TATA-less and contain Sp1 transcription factor binding sites upstream of the start site of transcription. Multiple transcripts of both CPT-Iα and CPT-Iβ exist, some of which may have roles in regulating fatty acid oxidation.",
author = "George Cook and Edwards Park",
year = "1999",
month = "1",
day = "1",
language = "English (US)",
volume = "318",
pages = "43--48",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Expression and regulation of carnitine palmitoyltransferase-Iα and -Iβ genes

AU - Cook, George

AU - Park, Edwards

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Two genes control expression of mitochondrial carnitine palmitoyltransferase-I (CPT-I), the enzyme that catalyzes the primary rate- controlling step in fatty acid oxidation. Two CPT-I isoforms have been found - a 'liver' isoform (CPT-Iα) expressed in most tissues, but not in skeletal muscles, and a 'muscle' isoform (CPT-Iβ) expressed in muscles and adipocytes. Liver CPT-Iα increases dramatically at birth, but heart CPT-Iα is abundant in the fetus and diminishes at birth. Insulin, thyroid hormone, and fatty acids regulate expression of CPT-Iα in liver, whereas electrical stimulation increases CPT-Iβ and decreases CPT-Iα in cardiac myocytes. Both genes are TATA-less and contain Sp1 transcription factor binding sites upstream of the start site of transcription. Multiple transcripts of both CPT-Iα and CPT-Iβ exist, some of which may have roles in regulating fatty acid oxidation.

AB - Two genes control expression of mitochondrial carnitine palmitoyltransferase-I (CPT-I), the enzyme that catalyzes the primary rate- controlling step in fatty acid oxidation. Two CPT-I isoforms have been found - a 'liver' isoform (CPT-Iα) expressed in most tissues, but not in skeletal muscles, and a 'muscle' isoform (CPT-Iβ) expressed in muscles and adipocytes. Liver CPT-Iα increases dramatically at birth, but heart CPT-Iα is abundant in the fetus and diminishes at birth. Insulin, thyroid hormone, and fatty acids regulate expression of CPT-Iα in liver, whereas electrical stimulation increases CPT-Iβ and decreases CPT-Iα in cardiac myocytes. Both genes are TATA-less and contain Sp1 transcription factor binding sites upstream of the start site of transcription. Multiple transcripts of both CPT-Iα and CPT-Iβ exist, some of which may have roles in regulating fatty acid oxidation.

UR - http://www.scopus.com/inward/record.url?scp=0033512292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033512292&partnerID=8YFLogxK

M3 - Article

VL - 318

SP - 43

EP - 48

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 1

ER -