Expression of c-myc protooncogene in primary cultures of human corneal stromal cells

Rao Gadiparthi, Janis L. Broeckx, Robert L. Church

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We have determined steady-state levels of c-myc mRNA in quiescent and serum-stimulated human corneal stromal cells. Steady-state levels of c-myc mRNA increased 6-fold following 2 hours of serum stimulation over levels observed at quiescence. A parallel increase in the rate of c-myc gene transcription was observed in serum-stimulated cells as compared to quiescent cells, indicating that the abundance of c-myc transcripts in corneal stromal cells during the transition from quiescence to proliferation is regulated mainly at the transcriptional level. These findings indicated that the expression of c-myc gene in human corneal stromal cells is regulated in a cell growth dependent manner in response to serum induction.

Original languageEnglish (US)
Pages (from-to)405-413
Number of pages9
JournalCurrent Eye Research
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1989

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Stromal Cells
myc Genes
Serum
Messenger RNA
Growth

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Expression of c-myc protooncogene in primary cultures of human corneal stromal cells. / Gadiparthi, Rao; Broeckx, Janis L.; Church, Robert L.

In: Current Eye Research, Vol. 8, No. 4, 01.01.1989, p. 405-413.

Research output: Contribution to journalArticle

Gadiparthi, Rao ; Broeckx, Janis L. ; Church, Robert L. / Expression of c-myc protooncogene in primary cultures of human corneal stromal cells. In: Current Eye Research. 1989 ; Vol. 8, No. 4. pp. 405-413.
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