Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium

Carlton D. Donald, Abhay Laddu, Priti Chandham, So Dug Lim, Cynthia Cohen, Mahul Amin, George L. Gerton, Fray F. Marshall, John A. Petros

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Current traditional pathological parameters, including staging and grading, are not sufficient in predicting outcome in patients with renal cell carcinoma (RCC). Acrogranin is an epithelial growth factor and has been demonstrated to play a role in teratocarcinogenesis and tumorigenesis. The aim of this study was to examine levels of acrogranin in renal cancer. Materials and Methods: Western blot analysis was performed on renal tissue protein lysates. In addition, immunohistochemical (IHC) analysis of acrogranin expression was conducted on tissue sections of various histological types and grades of RCC. Results: Western analysis showed that acrogranin levels were low in benign renal tissue and increased in malignant renal tissue. In addition, IHC revealed that high-grade RCC exhibited higher levels of expression than low-grade RCC and normal tissue. Conclusion: These data suggest that acrogranin may be a functionally important growth factor in RCC and may be a potential molecular marker for high-grade RCC.

Original languageEnglish (US)
Pages (from-to)3739-3742
Number of pages4
JournalAnticancer Research
Volume21
Issue number6 A
StatePublished - Dec 1 2001
Externally publishedYes

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Renal Cell Carcinoma
Epithelium
Kidney
Intercellular Signaling Peptides and Proteins
Kidney Neoplasms
granulin precursor protein
Carcinogenesis
Western Blotting
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Donald, C. D., Laddu, A., Chandham, P., Lim, S. D., Cohen, C., Amin, M., ... Petros, J. A. (2001). Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. Anticancer Research, 21(6 A), 3739-3742.

Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. / Donald, Carlton D.; Laddu, Abhay; Chandham, Priti; Lim, So Dug; Cohen, Cynthia; Amin, Mahul; Gerton, George L.; Marshall, Fray F.; Petros, John A.

In: Anticancer Research, Vol. 21, No. 6 A, 01.12.2001, p. 3739-3742.

Research output: Contribution to journalArticle

Donald, CD, Laddu, A, Chandham, P, Lim, SD, Cohen, C, Amin, M, Gerton, GL, Marshall, FF & Petros, JA 2001, 'Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium', Anticancer Research, vol. 21, no. 6 A, pp. 3739-3742.
Donald, Carlton D. ; Laddu, Abhay ; Chandham, Priti ; Lim, So Dug ; Cohen, Cynthia ; Amin, Mahul ; Gerton, George L. ; Marshall, Fray F. ; Petros, John A. / Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. In: Anticancer Research. 2001 ; Vol. 21, No. 6 A. pp. 3739-3742.
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AU - Donald, Carlton D.

AU - Laddu, Abhay

AU - Chandham, Priti

AU - Lim, So Dug

AU - Cohen, Cynthia

AU - Amin, Mahul

AU - Gerton, George L.

AU - Marshall, Fray F.

AU - Petros, John A.

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AB - Background: Current traditional pathological parameters, including staging and grading, are not sufficient in predicting outcome in patients with renal cell carcinoma (RCC). Acrogranin is an epithelial growth factor and has been demonstrated to play a role in teratocarcinogenesis and tumorigenesis. The aim of this study was to examine levels of acrogranin in renal cancer. Materials and Methods: Western blot analysis was performed on renal tissue protein lysates. In addition, immunohistochemical (IHC) analysis of acrogranin expression was conducted on tissue sections of various histological types and grades of RCC. Results: Western analysis showed that acrogranin levels were low in benign renal tissue and increased in malignant renal tissue. In addition, IHC revealed that high-grade RCC exhibited higher levels of expression than low-grade RCC and normal tissue. Conclusion: These data suggest that acrogranin may be a functionally important growth factor in RCC and may be a potential molecular marker for high-grade RCC.

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