Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse

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Abstract

Huntingtin-associated protein 1 (HAP1) interacts with the product of the Huntington's disease gene. To investigate the function of Hap1 in development and in the adult mouse, we have examined the expression of Hap1 by northern analysis and in situ hybridization histochemistry. Hap1 expression is first detected in the embryonic day 8.5 (E8.5) neuroepithelium. Expression persists throughout development, predominantly in the brain and spinal cord, and to a lesser extent in enteric neurons and abdominal sympathetic ganglia. In the adult, Hap1 expression is detected not only in the brain but also in the ovary, testis, and the intermediate lobe of the pituitary. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Volume282
Issue number1-2
DOIs
StatePublished - Mar 17 2000

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Intermediate Pituitary Gland
Sympathetic Ganglia
Huntington Disease
Brain
Genes
In Situ Hybridization
Testis
Ovary
Spinal Cord
Neurons
Huntingtin Protein

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse. / Dragatsis, Ioannis; Dietrich, Paula; Zeitlin, Scott.

In: Neuroscience Letters, Vol. 282, No. 1-2, 17.03.2000, p. 37-40.

Research output: Contribution to journalArticle

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