Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: Are angiomyolipomas neoplasms of stem cells?

Dug Lim So, William Stallcup, Benjamin Lefkove, Baskaran Govindarajan, Sing Au Kit, Hope Northrup, Deborah Lang, David E. Fisher, Avani Patel, Mahul Amin, Jack L. Arbiser

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Angiomyolipomas are benign tumors of the kidney which express phenotypes of smooth muscle, fat, and melanocytes. These tumors appear with increased frequency in the autosomal dominant disorder tuberous sclerosis and are the leading cause of morbidity in adults with tuberous sclerosis. While benign, these tumors are capable of provoking life threatening hemorrhage and replacement of the kidney parenchyma, resulting in renal failure. The histogenesis of these tumors is currently unclear, although currently, we believe these tumors arise from "perivascular epithelioid cells" of which no normal counterpart has been convincingly demonstrated. Recently, stem cell precursors have been recognized that can give rise to smooth muscle and melanocytes. These precursors have been shown to express the neural stem cell marker NG2 and L1. In order to determine whether angiomyolipomas, which exhibit smooth muscle and melanocytic phenotypes, express NG2 and L1, we performed immunocytochemistry on a cell line derived from a human angiomyolipoma, and found that these cells are uniformly positive. Immunohistochemistry of human angiomyolipoma specimens revealed uniform staining of tumor cells, while renal cell carcinomas revealed positivity only of angiogenic vessels. These results support a novel histogenesis of angiomyolipoma as a defect in differentiation of stem cell precursors.

Original languageEnglish (US)
Pages (from-to)160-165
Number of pages6
JournalMolecular Medicine
Volume13
Issue number3-4
DOIs
StatePublished - Mar 1 2007

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Angiomyolipoma
Neural Stem Cells
Stem Cells
Smooth Muscle
Tuberous Sclerosis
Melanocytes
Neoplasms
Perivascular Epithelioid Cell Neoplasms
Immunohistochemistry
Phenotype
Kidney
Renal Cell Carcinoma
Renal Insufficiency
Fats
Staining and Labeling
Hemorrhage
Morbidity
Cell Line

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

So, D. L., Stallcup, W., Lefkove, B., Govindarajan, B., Kit, S. A., Northrup, H., ... Arbiser, J. L. (2007). Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: Are angiomyolipomas neoplasms of stem cells? Molecular Medicine, 13(3-4), 160-165. https://doi.org/10.2119/2006-00070.Lim

Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma : Are angiomyolipomas neoplasms of stem cells? / So, Dug Lim; Stallcup, William; Lefkove, Benjamin; Govindarajan, Baskaran; Kit, Sing Au; Northrup, Hope; Lang, Deborah; Fisher, David E.; Patel, Avani; Amin, Mahul; Arbiser, Jack L.

In: Molecular Medicine, Vol. 13, No. 3-4, 01.03.2007, p. 160-165.

Research output: Contribution to journalArticle

So, DL, Stallcup, W, Lefkove, B, Govindarajan, B, Kit, SA, Northrup, H, Lang, D, Fisher, DE, Patel, A, Amin, M & Arbiser, JL 2007, 'Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: Are angiomyolipomas neoplasms of stem cells?', Molecular Medicine, vol. 13, no. 3-4, pp. 160-165. https://doi.org/10.2119/2006-00070.Lim
So, Dug Lim ; Stallcup, William ; Lefkove, Benjamin ; Govindarajan, Baskaran ; Kit, Sing Au ; Northrup, Hope ; Lang, Deborah ; Fisher, David E. ; Patel, Avani ; Amin, Mahul ; Arbiser, Jack L. / Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma : Are angiomyolipomas neoplasms of stem cells?. In: Molecular Medicine. 2007 ; Vol. 13, No. 3-4. pp. 160-165.
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