Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes

Eduard N. Lavrentyev, Shannon G. Matta, George Cook

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Inhibition of carnitine palmitoyltransferase-I (CPT-I) activity in the brain has been shown to decrease food intake in rats. We examined the expression of mRNA encoding all three known CPT-I isoforms (α, β, and γ) in 10 different major regions of the rat brain in normal, chow-fed rats, in fasting rats, and in insulin-dependent diabetic rats. Compared with the effects of fasting and diabetes on CPT-I mRNA in the liver and heart, there was either less effect or no effect depending on the particular brain region examined. These results suggest that the regulation of CPT-I mRNA levels is different in the brain than in other tissues. A surprising result of this study was the discovery of very high, unique expression of CPT-Iβ (the muscle isoform) in the cerebellum.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume315
Issue number1
DOIs
StatePublished - Feb 27 2004

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Carnitine O-Palmitoyltransferase
Medical problems
Rats
Fasting
Brain
Protein Isoforms
Messenger RNA
Liver
Cerebellum
Muscle
Eating
Insulin
Tissue
Muscles

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes. / Lavrentyev, Eduard N.; Matta, Shannon G.; Cook, George.

In: Biochemical and Biophysical Research Communications, Vol. 315, No. 1, 27.02.2004, p. 174-178.

Research output: Contribution to journalArticle

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