External Validation of the Medication Taper Complexity Score for Methadone Tapers in Children With Opioid Abstinence Syndrome

Peter N. Johnson, Jamie L. Miller, Tracy Hagemann, Christine Castro, Donald Harrison

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Methadone is commonly prescribed for children with opioid abstinence syndrome (OAS) as a taper schedule over several days to weeks. The Medication Taper Complexity Score (MTCS) was developed to evaluate outpatient methadone tapers. Objective: To further validate the MTCS and determine if it is a reliable tool for clinicians to use to assess the complexity of methadone tapers for OAS. Methods: An expert panel of pediatric clinical pharmacists was convened. Panel members were provided 9 methadone tapers (ie, "easy," "medium," and "difficult") to determine construct and face validity of the MTCS. The primary objective was to further establish reliability and construct/face validity of the MTCS. The secondary objective was to assess the reliability of the MTCS within and between tapers. Instrument reliability was assessed using a Pearson correlation coefficient; with 0.8 as the minimum acceptable coefficient. Construct (divergent) validity was assessed via a repeated-measures ANOVA analysis (Bonferroni post hoc analyses) of the mean scores provided by panel members. Results: Six panel members were recruited from various geographical locations. Panel members had 18.3 ± 5.5 years of experience, with practice expertise in general pediatrics, hematology/oncology, and the pediatric and neonatal intensive care unit. The MTCS had a reliability coefficient of.9949. There was vivid discrimination between the easy, medium, and difficult tapers; P =.001. The panel recommended minor modifications to the MTCS. Conclusions: The MTCS was found to be a reliable and valid tool. Overall, the panel felt that the MTCS was easy to use and had potential applications in both practice and research.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalAnnals of Pharmacotherapy
Volume48
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Methadone
Opioid Analgesics
Reproducibility of Results
Pediatrics
Pediatric Intensive Care Units
Neonatal Intensive Care Units
Hematology
Pharmacists
Analysis of Variance
Appointments and Schedules
Outpatients
Research

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

External Validation of the Medication Taper Complexity Score for Methadone Tapers in Children With Opioid Abstinence Syndrome. / Johnson, Peter N.; Miller, Jamie L.; Hagemann, Tracy; Castro, Christine; Harrison, Donald.

In: Annals of Pharmacotherapy, Vol. 48, No. 2, 01.02.2014, p. 187-195.

Research output: Contribution to journalArticle

Johnson, Peter N. ; Miller, Jamie L. ; Hagemann, Tracy ; Castro, Christine ; Harrison, Donald. / External Validation of the Medication Taper Complexity Score for Methadone Tapers in Children With Opioid Abstinence Syndrome. In: Annals of Pharmacotherapy. 2014 ; Vol. 48, No. 2. pp. 187-195.
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