Extracellular matrix remodeling in heart failure

A role for de novo angiotensin II generation

Research output: Contribution to journalReview article

467 Citations (Scopus)

Abstract

A structural remodeling of the extracellular matrix is an important determinant of abnormal ventricular function and reduced threshold for arrhythmia(s) in chronic cardiac failure. Phenotypically transformed fibroblast-like cells, or myoFbs, appear at sites of repair and are responsible for fibrogenesis. The contribution of myoFbs to repair in the heart is independent of the etiologic basis of injury, the location of repair, hemodynamic factors, hypertrophy, or circulating RAAS activation. At sites of repair, myoFbs express components requisite to de novo generation of Ang II, which has important autocrine and paracrine properties that regulate various molecular and cellular components of repair, including expression of the fibrogenic peptide TGF-β 1 .

Original languageEnglish (US)
Pages (from-to)4065-4082
Number of pages18
JournalCirculation
Volume96
Issue number11
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Ventricular Function
Angiotensin II
Hypertrophy
Extracellular Matrix
Cardiac Arrhythmias
Heart Failure
Fibroblasts
Hemodynamics
Peptides
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Extracellular matrix remodeling in heart failure : A role for de novo angiotensin II generation. / Weber, Karl.

In: Circulation, Vol. 96, No. 11, 01.01.1997, p. 4065-4082.

Research output: Contribution to journalReview article

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