Extracellular Vesicles

Intercellular Mediators in Alcohol-Induced Pathologies

Mohammad A. Rahman, Benjamin J. Patters, Sunitha Kodidela, Santosh Kumar

Research output: Contribution to journalReview article

Abstract

Though alcoholic liver injury plays the primary role in direct alcohol-related morbidity, alcohol consumption is also interlinked with many other diseases in extra-hepatic tissues/organs. The mechanism of alcoholic tissue injury is well documented, however the mechanisms that affect extra-hepatic tissues have not yet been well defined. Extracellular vesicles (EVs) such as exosomes and microvesicles, have been identified as key components of alcohol-induced extra-hepatic effects. We have reviewed the recent findings on the potential impact of alcohol-modified EVs/exosomes production and their downstream effects on extra-hepatic tissues. In this review, we discuss the available information on the cross-talk between hepatocytes and immune cells via EV/exosomal cargos (miRNA, mRNA, protein, etc.) in alcoholic liver diseases. We also discuss the effects of alcohol exposure on the contents of EVs/exosomes derived from various extra-hepatic tissues and their associated pathological consequences on recipient cells. Finally, we speculate on other potential EV/exosomal agents that may mediate alcohol-induced tissue damage. [Figure not available: see fulltext.].

Original languageEnglish (US)
JournalJournal of Neuroimmune Pharmacology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Alcohols
Pathology
Exosomes
Liver
Alcoholic Liver Diseases
Wounds and Injuries
MicroRNAs
Alcohol Drinking
Extracellular Vesicles
Hepatocytes
Morbidity
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Extracellular Vesicles : Intercellular Mediators in Alcohol-Induced Pathologies. / Rahman, Mohammad A.; Patters, Benjamin J.; Kodidela, Sunitha; Kumar, Santosh.

In: Journal of Neuroimmune Pharmacology, 01.01.2019.

Research output: Contribution to journalReview article

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