Factors Affecting Health-Related Quality of Life in Children Undergoing Curative Treatment for Cancer

A Review of the Literature

Tha’er G. Momani, Donna Hathaway, Belinda N. Mandrell

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Background: Health-related quality of life (HRQoL) is an important measure to evaluate a child’s reported treatment experience. Although there are numerous studies of HRQoL in children undergoing curative cancer treatment, there is limited literature on factors that influence this. Objective: To review published studies that describe the HRQoL and associated factors in children undergoing curative cancer treatment. Method: Full-text publications in English from January 2005 to March 2013 were searched in PubMed, PsychINFO, and CINAHL for children ≤18 years of age undergoing curative cancer treatment. HRQoL-associated factors were categorized as cancer diagnosis, treatment, child, family, and community. Results: Twenty-six studies met the inclusion criteria. The most frequently used generic and cancer-specific instruments were PedsQL (Pediatric Quality of Life Inventory) Generic and PedsQL Cancer, respectively. Cancer diagnosis and treatment were the most frequently identified variables; fewer studies measured family and community domains. Gender, treatment intensity, type of cancer treatments, time in treatment, and cancer diagnosis were correlated with HRQoL. Conclusion: Our study highlights the need to develop interventions based on diagnosis and treatment regimen to improve the HRQoL in children undergoing curative cancer treatment.

Original languageEnglish (US)
Pages (from-to)228-240
Number of pages13
JournalJournal of Pediatric Oncology Nursing
Volume33
Issue number3
DOIs
StatePublished - Jan 1 2015

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Therapeutics
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All Science Journal Classification (ASJC) codes

  • Pediatrics
  • Oncology(nursing)

Cite this

Factors Affecting Health-Related Quality of Life in Children Undergoing Curative Treatment for Cancer : A Review of the Literature. / Momani, Tha’er G.; Hathaway, Donna; Mandrell, Belinda N.

In: Journal of Pediatric Oncology Nursing, Vol. 33, No. 3, 01.01.2015, p. 228-240.

Research output: Contribution to journalReview article

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abstract = "Background: Health-related quality of life (HRQoL) is an important measure to evaluate a child’s reported treatment experience. Although there are numerous studies of HRQoL in children undergoing curative cancer treatment, there is limited literature on factors that influence this. Objective: To review published studies that describe the HRQoL and associated factors in children undergoing curative cancer treatment. Method: Full-text publications in English from January 2005 to March 2013 were searched in PubMed, PsychINFO, and CINAHL for children ≤18 years of age undergoing curative cancer treatment. HRQoL-associated factors were categorized as cancer diagnosis, treatment, child, family, and community. Results: Twenty-six studies met the inclusion criteria. The most frequently used generic and cancer-specific instruments were PedsQL (Pediatric Quality of Life Inventory) Generic and PedsQL Cancer, respectively. Cancer diagnosis and treatment were the most frequently identified variables; fewer studies measured family and community domains. Gender, treatment intensity, type of cancer treatments, time in treatment, and cancer diagnosis were correlated with HRQoL. Conclusion: Our study highlights the need to develop interventions based on diagnosis and treatment regimen to improve the HRQoL in children undergoing curative cancer treatment.",
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N2 - Background: Health-related quality of life (HRQoL) is an important measure to evaluate a child’s reported treatment experience. Although there are numerous studies of HRQoL in children undergoing curative cancer treatment, there is limited literature on factors that influence this. Objective: To review published studies that describe the HRQoL and associated factors in children undergoing curative cancer treatment. Method: Full-text publications in English from January 2005 to March 2013 were searched in PubMed, PsychINFO, and CINAHL for children ≤18 years of age undergoing curative cancer treatment. HRQoL-associated factors were categorized as cancer diagnosis, treatment, child, family, and community. Results: Twenty-six studies met the inclusion criteria. The most frequently used generic and cancer-specific instruments were PedsQL (Pediatric Quality of Life Inventory) Generic and PedsQL Cancer, respectively. Cancer diagnosis and treatment were the most frequently identified variables; fewer studies measured family and community domains. Gender, treatment intensity, type of cancer treatments, time in treatment, and cancer diagnosis were correlated with HRQoL. Conclusion: Our study highlights the need to develop interventions based on diagnosis and treatment regimen to improve the HRQoL in children undergoing curative cancer treatment.

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