Factors influencing risk-based care of the childhood cancer survivor in the 21st century

Stephanie B. Dixon, Kari L. Bjornard, Nicole M. Alberts, Gregory Armstrong, Tara M. Brinkman, Wassim Chemaitilly, Matthew J. Ehrhardt, Israel Fernandez-Pineda, Lisa M. Force, Todd M. Gibson, Daniel M. Green, Carrie R. Howell, Sue C. Kaste, Anne C. Kirchhoff, James L. Klosky, Kevin R. Krull, John T. Lucas, Daniel A. Mulrooney, Kirsten K. Ness, Carmen L. Wilson & 3 others Yutaka Yasui, Leslie L. Robison, Melissa M. Hudson

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population. Furthermore, although current long-term follow-up guidelines comprehensively address specific therapy-related risks and provide screening recommendations, the risk profile of the population continues to evolve with ongoing modification of treatment strategies and the emergence of novel therapeutics. To address the multifactorial modifiers of cancer treatment-related health risk and evolving treatment approaches, a patient-centered and risk-adapted approach to care that often requires a multidisciplinary team approach, including medical and behavioral providers, is necessary for this population. CA Cancer J Clin 2018;68:133-152.

Original languageEnglish (US)
Pages (from-to)133-152
Number of pages20
JournalCA Cancer Journal for Clinicians
Volume68
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

Survivors
Second Primary Neoplasms
Neoplasms
Population
Therapeutics
Health Behavior
Comorbidity
Survival Rate
Demography
Guidelines
Health
Research

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cite this

Dixon, S. B., Bjornard, K. L., Alberts, N. M., Armstrong, G., Brinkman, T. M., Chemaitilly, W., ... Hudson, M. M. (2018). Factors influencing risk-based care of the childhood cancer survivor in the 21st century. CA Cancer Journal for Clinicians, 68(2), 133-152. https://doi.org/10.3322/caac.21445

Factors influencing risk-based care of the childhood cancer survivor in the 21st century. / Dixon, Stephanie B.; Bjornard, Kari L.; Alberts, Nicole M.; Armstrong, Gregory; Brinkman, Tara M.; Chemaitilly, Wassim; Ehrhardt, Matthew J.; Fernandez-Pineda, Israel; Force, Lisa M.; Gibson, Todd M.; Green, Daniel M.; Howell, Carrie R.; Kaste, Sue C.; Kirchhoff, Anne C.; Klosky, James L.; Krull, Kevin R.; Lucas, John T.; Mulrooney, Daniel A.; Ness, Kirsten K.; Wilson, Carmen L.; Yasui, Yutaka; Robison, Leslie L.; Hudson, Melissa M.

In: CA Cancer Journal for Clinicians, Vol. 68, No. 2, 01.03.2018, p. 133-152.

Research output: Contribution to journalReview article

Dixon, SB, Bjornard, KL, Alberts, NM, Armstrong, G, Brinkman, TM, Chemaitilly, W, Ehrhardt, MJ, Fernandez-Pineda, I, Force, LM, Gibson, TM, Green, DM, Howell, CR, Kaste, SC, Kirchhoff, AC, Klosky, JL, Krull, KR, Lucas, JT, Mulrooney, DA, Ness, KK, Wilson, CL, Yasui, Y, Robison, LL & Hudson, MM 2018, 'Factors influencing risk-based care of the childhood cancer survivor in the 21st century', CA Cancer Journal for Clinicians, vol. 68, no. 2, pp. 133-152. https://doi.org/10.3322/caac.21445
Dixon, Stephanie B. ; Bjornard, Kari L. ; Alberts, Nicole M. ; Armstrong, Gregory ; Brinkman, Tara M. ; Chemaitilly, Wassim ; Ehrhardt, Matthew J. ; Fernandez-Pineda, Israel ; Force, Lisa M. ; Gibson, Todd M. ; Green, Daniel M. ; Howell, Carrie R. ; Kaste, Sue C. ; Kirchhoff, Anne C. ; Klosky, James L. ; Krull, Kevin R. ; Lucas, John T. ; Mulrooney, Daniel A. ; Ness, Kirsten K. ; Wilson, Carmen L. ; Yasui, Yutaka ; Robison, Leslie L. ; Hudson, Melissa M. / Factors influencing risk-based care of the childhood cancer survivor in the 21st century. In: CA Cancer Journal for Clinicians. 2018 ; Vol. 68, No. 2. pp. 133-152.
@article{3c92a8dfc90f4f01ae6c5e21dfb747a6,
title = "Factors influencing risk-based care of the childhood cancer survivor in the 21st century",
abstract = "The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population. Furthermore, although current long-term follow-up guidelines comprehensively address specific therapy-related risks and provide screening recommendations, the risk profile of the population continues to evolve with ongoing modification of treatment strategies and the emergence of novel therapeutics. To address the multifactorial modifiers of cancer treatment-related health risk and evolving treatment approaches, a patient-centered and risk-adapted approach to care that often requires a multidisciplinary team approach, including medical and behavioral providers, is necessary for this population. CA Cancer J Clin 2018;68:133-152.",
author = "Dixon, {Stephanie B.} and Bjornard, {Kari L.} and Alberts, {Nicole M.} and Gregory Armstrong and Brinkman, {Tara M.} and Wassim Chemaitilly and Ehrhardt, {Matthew J.} and Israel Fernandez-Pineda and Force, {Lisa M.} and Gibson, {Todd M.} and Green, {Daniel M.} and Howell, {Carrie R.} and Kaste, {Sue C.} and Kirchhoff, {Anne C.} and Klosky, {James L.} and Krull, {Kevin R.} and Lucas, {John T.} and Mulrooney, {Daniel A.} and Ness, {Kirsten K.} and Wilson, {Carmen L.} and Yutaka Yasui and Robison, {Leslie L.} and Hudson, {Melissa M.}",
year = "2018",
month = "3",
day = "1",
doi = "10.3322/caac.21445",
language = "English (US)",
volume = "68",
pages = "133--152",
journal = "Ca-A Cancer Journal for Clinicians",
issn = "0007-9235",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Factors influencing risk-based care of the childhood cancer survivor in the 21st century

AU - Dixon, Stephanie B.

AU - Bjornard, Kari L.

AU - Alberts, Nicole M.

AU - Armstrong, Gregory

AU - Brinkman, Tara M.

AU - Chemaitilly, Wassim

AU - Ehrhardt, Matthew J.

AU - Fernandez-Pineda, Israel

AU - Force, Lisa M.

AU - Gibson, Todd M.

AU - Green, Daniel M.

AU - Howell, Carrie R.

AU - Kaste, Sue C.

AU - Kirchhoff, Anne C.

AU - Klosky, James L.

AU - Krull, Kevin R.

AU - Lucas, John T.

AU - Mulrooney, Daniel A.

AU - Ness, Kirsten K.

AU - Wilson, Carmen L.

AU - Yasui, Yutaka

AU - Robison, Leslie L.

AU - Hudson, Melissa M.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population. Furthermore, although current long-term follow-up guidelines comprehensively address specific therapy-related risks and provide screening recommendations, the risk profile of the population continues to evolve with ongoing modification of treatment strategies and the emergence of novel therapeutics. To address the multifactorial modifiers of cancer treatment-related health risk and evolving treatment approaches, a patient-centered and risk-adapted approach to care that often requires a multidisciplinary team approach, including medical and behavioral providers, is necessary for this population. CA Cancer J Clin 2018;68:133-152.

AB - The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population. Furthermore, although current long-term follow-up guidelines comprehensively address specific therapy-related risks and provide screening recommendations, the risk profile of the population continues to evolve with ongoing modification of treatment strategies and the emergence of novel therapeutics. To address the multifactorial modifiers of cancer treatment-related health risk and evolving treatment approaches, a patient-centered and risk-adapted approach to care that often requires a multidisciplinary team approach, including medical and behavioral providers, is necessary for this population. CA Cancer J Clin 2018;68:133-152.

UR - http://www.scopus.com/inward/record.url?scp=85041096722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041096722&partnerID=8YFLogxK

U2 - 10.3322/caac.21445

DO - 10.3322/caac.21445

M3 - Review article

VL - 68

SP - 133

EP - 152

JO - Ca-A Cancer Journal for Clinicians

JF - Ca-A Cancer Journal for Clinicians

SN - 0007-9235

IS - 2

ER -