Failure of pentoxifylline to enhance skin flap survival in the rat

A. M. Freedman, G. L. Hyde, Edward Luce

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effect of pentoxifylline, a hemorheological agent that increases erythrocyte flexibility and augments capillary blood flow, on the survival of the dorsal skin flap of the rat was studied. An experimental group received intraperitoneal injections of pentoxifylline twice daily, 50 mg/kg/day, and a control group was given identical volumes of saline. Standard McFarlane flaps sized 4 x 9 cm (n = 22) and narrower 2 x 6-cm flaps (n = 18) were constructed 14 days later. After a postoperative observation period of 7 days, no significant difference in tissue survival between the pentoxifylline-treated animals and the controls was found in either flap model. Fourteen days preoperative treatment with pentoxifylline appeared to have no effect on flap survival.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalAnnals of Plastic Surgery
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Pentoxifylline
Skin
Tissue Survival
Intraperitoneal Injections
Postoperative Period
Erythrocytes
Observation
Control Groups
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Failure of pentoxifylline to enhance skin flap survival in the rat. / Freedman, A. M.; Hyde, G. L.; Luce, Edward.

In: Annals of Plastic Surgery, Vol. 23, No. 1, 01.01.1989, p. 31-34.

Research output: Contribution to journalArticle

Freedman, A. M. ; Hyde, G. L. ; Luce, Edward. / Failure of pentoxifylline to enhance skin flap survival in the rat. In: Annals of Plastic Surgery. 1989 ; Vol. 23, No. 1. pp. 31-34.
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