Failure to confirm consistent stimulation of growth hormone by diazepam

E. R. Levin, Burt Sharp, H. E. Carlson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release. Normal volunteers were therefore examined for anterior pituitary responsiveness to 10 mg diazepam i.v. and p.o. The drug had no significant effect on the secretion of prolactin or thyrotropin when compared to control saline injections in all subjects. Growth hormone response was variable; serum growth hormone increased significantly in only 4 of 10 patients after i.v. diazepam and in only 1 of 7 subjects tested with oral diazepam. Serum cortisol rose in only 1 subject, precluding a stress-related explanation for the increase in growth hormone. We conclude that diazepam inconsistently stimulates growth hormone secretion and should not be relied upon as a test of growth hormone reserve.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalHormone Research
Volume19
Issue number2
DOIs
StatePublished - Jan 1 1984

Fingerprint

Diazepam
Growth Hormone
Pituitary Hormones
Thyrotropin
Serum
Prolactin
Hydrocortisone
Healthy Volunteers
Injections
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Failure to confirm consistent stimulation of growth hormone by diazepam. / Levin, E. R.; Sharp, Burt; Carlson, H. E.

In: Hormone Research, Vol. 19, No. 2, 01.01.1984, p. 86-90.

Research output: Contribution to journalArticle

Levin, E. R. ; Sharp, Burt ; Carlson, H. E. / Failure to confirm consistent stimulation of growth hormone by diazepam. In: Hormone Research. 1984 ; Vol. 19, No. 2. pp. 86-90.
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