Familial lung cancer: A brief history from the earliestwork to the most recent studies

Anthony M. Musolf, Claire Simpson, Mariza De Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Yafang Li, Ming You, Elena Y. Kupert, Marshall W. Anderson, Ann G. Schwartz, Susan M. Pinney, Christopher I. Amos, Joan E. Bailey-Wilson

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23–25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.

Original languageEnglish (US)
Article number36
JournalGenes
Volume8
Issue number1
DOIs
StatePublished - Jan 17 2017

Fingerprint

Lung Neoplasms
History
Alleles
Penetrance
Germ-Line Mutation
Disease Susceptibility
Genetic Association Studies
Genetic Predisposition to Disease
Genomics
Neoplasms
Smoking

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Musolf, A. M., Simpson, C., De Andrade, M., Mandal, D., Gaba, C., Yang, P., ... Bailey-Wilson, J. E. (2017). Familial lung cancer: A brief history from the earliestwork to the most recent studies. Genes, 8(1), [36]. https://doi.org/10.3390/genes8010036

Familial lung cancer : A brief history from the earliestwork to the most recent studies. / Musolf, Anthony M.; Simpson, Claire; De Andrade, Mariza; Mandal, Diptasri; Gaba, Colette; Yang, Ping; Li, Yafang; You, Ming; Kupert, Elena Y.; Anderson, Marshall W.; Schwartz, Ann G.; Pinney, Susan M.; Amos, Christopher I.; Bailey-Wilson, Joan E.

In: Genes, Vol. 8, No. 1, 36, 17.01.2017.

Research output: Contribution to journalReview article

Musolf, AM, Simpson, C, De Andrade, M, Mandal, D, Gaba, C, Yang, P, Li, Y, You, M, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2017, 'Familial lung cancer: A brief history from the earliestwork to the most recent studies', Genes, vol. 8, no. 1, 36. https://doi.org/10.3390/genes8010036
Musolf, Anthony M. ; Simpson, Claire ; De Andrade, Mariza ; Mandal, Diptasri ; Gaba, Colette ; Yang, Ping ; Li, Yafang ; You, Ming ; Kupert, Elena Y. ; Anderson, Marshall W. ; Schwartz, Ann G. ; Pinney, Susan M. ; Amos, Christopher I. ; Bailey-Wilson, Joan E. / Familial lung cancer : A brief history from the earliestwork to the most recent studies. In: Genes. 2017 ; Vol. 8, No. 1.
@article{b0b061fd7f6449dfbe0a4a0760aed8e5,
title = "Familial lung cancer: A brief history from the earliestwork to the most recent studies",
abstract = "Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23–25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.",
author = "Musolf, {Anthony M.} and Claire Simpson and {De Andrade}, Mariza and Diptasri Mandal and Colette Gaba and Ping Yang and Yafang Li and Ming You and Kupert, {Elena Y.} and Anderson, {Marshall W.} and Schwartz, {Ann G.} and Pinney, {Susan M.} and Amos, {Christopher I.} and Bailey-Wilson, {Joan E.}",
year = "2017",
month = "1",
day = "17",
doi = "10.3390/genes8010036",
language = "English (US)",
volume = "8",
journal = "Genes",
issn = "2073-4425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

TY - JOUR

T1 - Familial lung cancer

T2 - A brief history from the earliestwork to the most recent studies

AU - Musolf, Anthony M.

AU - Simpson, Claire

AU - De Andrade, Mariza

AU - Mandal, Diptasri

AU - Gaba, Colette

AU - Yang, Ping

AU - Li, Yafang

AU - You, Ming

AU - Kupert, Elena Y.

AU - Anderson, Marshall W.

AU - Schwartz, Ann G.

AU - Pinney, Susan M.

AU - Amos, Christopher I.

AU - Bailey-Wilson, Joan E.

PY - 2017/1/17

Y1 - 2017/1/17

N2 - Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23–25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.

AB - Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23–25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.

UR - http://www.scopus.com/inward/record.url?scp=85010289421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010289421&partnerID=8YFLogxK

U2 - 10.3390/genes8010036

DO - 10.3390/genes8010036

M3 - Review article

AN - SCOPUS:85010289421

VL - 8

JO - Genes

JF - Genes

SN - 2073-4425

IS - 1

M1 - 36

ER -