Familial renal oncocytoma

Clinicopathological study of 5 families

Gregor Weirich, Gladys Glenn, Kerstin Junker, Maria Merino, Stefan Störkel, Irina Lubensky, Peter Choyke, Svetlana Pack, Mahul Amin, Mcclellan M. Walther, W. Marston Linehan, Berton Zbar

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Purpose: We analyzed familial renal oncocytoma to provide a foundation for studies aimed at defining genes involved in the pathogenesis of renal oncocytoma. Materials and Methods: We describe 5 families with multiple members affected with renal oncocytoma. Tumors were analyzed pathologically, and affected and nonaffected members were screened clinically and genetically. Results: We identified 12 affected male and 3 affected female (ratio 4:1) individuals in the 5 families. In affected family members renal oncocytomas were often multiple and bilateral. No metastatic disease was observed. Most renal oncocytomas were detected incidentally in asymptomatic individuals or during screening of asymptomatic members of renal oncocytoma families. One identical twin pair was affected with bilateral multiple renal oncocytomas. Conclusions: Renal oncocytoma may be inherited in some families.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalJournal of Urology
Volume160
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Monozygotic Twins
Renal oncocytoma
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Weirich, G., Glenn, G., Junker, K., Merino, M., Störkel, S., Lubensky, I., ... Zbar, B. (1998). Familial renal oncocytoma: Clinicopathological study of 5 families. Journal of Urology, 160(2), 335-340. https://doi.org/10.1016/S0022-5347(01)62888-X

Familial renal oncocytoma : Clinicopathological study of 5 families. / Weirich, Gregor; Glenn, Gladys; Junker, Kerstin; Merino, Maria; Störkel, Stefan; Lubensky, Irina; Choyke, Peter; Pack, Svetlana; Amin, Mahul; Walther, Mcclellan M.; Linehan, W. Marston; Zbar, Berton.

In: Journal of Urology, Vol. 160, No. 2, 01.01.1998, p. 335-340.

Research output: Contribution to journalArticle

Weirich, G, Glenn, G, Junker, K, Merino, M, Störkel, S, Lubensky, I, Choyke, P, Pack, S, Amin, M, Walther, MM, Linehan, WM & Zbar, B 1998, 'Familial renal oncocytoma: Clinicopathological study of 5 families', Journal of Urology, vol. 160, no. 2, pp. 335-340. https://doi.org/10.1016/S0022-5347(01)62888-X
Weirich G, Glenn G, Junker K, Merino M, Störkel S, Lubensky I et al. Familial renal oncocytoma: Clinicopathological study of 5 families. Journal of Urology. 1998 Jan 1;160(2):335-340. https://doi.org/10.1016/S0022-5347(01)62888-X
Weirich, Gregor ; Glenn, Gladys ; Junker, Kerstin ; Merino, Maria ; Störkel, Stefan ; Lubensky, Irina ; Choyke, Peter ; Pack, Svetlana ; Amin, Mahul ; Walther, Mcclellan M. ; Linehan, W. Marston ; Zbar, Berton. / Familial renal oncocytoma : Clinicopathological study of 5 families. In: Journal of Urology. 1998 ; Vol. 160, No. 2. pp. 335-340.
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