Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life

Qingju Wang, Markku Alén, Arja Lyytikäinen, Leiting Xu, Frances Tylavsky, Urho M. Kujala, Heikki Kröger, Ego Seeman, Sulin Cheng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Familial resemblance and diversity in bone structure and strength in adulthood are determined in part during growth. Whether these characteristics are established during gestation or shortly after birth is not known. Total-body, lumbar spine, and femoral neck size and mass and indices of tibial bending strength and distal radial compressive strength were measured using bone densitometry and quantitative computed tomography in 236 girls at 18.5 years of age. Among them, 219, 141, and 105 girls had crown-heel length (CHL) and weight recorded at birth and at 6 and 12 months of age, and then height and weight were recorded at 3, 5, 10, 13, and 15 years of age in 181, 176, 127, 111, and 228 girls, respectively. Of these girls, 101 and 93 girls also had bone structure assessed at 11 and 13 years of age, respectively. Similar bonemeasurementsweremade once in 78mother-father pairs. CHL and weight at birth did not correlate or did soweaklywith bone traits in girls at 18 years of age. By contrast, CHL at 6months correlated with the height, bone traits, and strength at puberty and at 18 years of age (r=0.24-0.56, p<.001) in girls and with their parents' height and bone traits (r=0.15-0.37, p<.05).When the girls' CHL at 6 months was stratified into quartiles, the absolute and relative differences in bone traits observed at puberty (∼11.5 years) were maintained as these traits tracked during the ensuing 7 years. Similarly, weight at 6 months correlated with the girls' bone traits at puberty and 18 years of age (r=0.22-0.55, p<.05). During puberty and at 18 years of age, the girls' bone traits correlated with the corresponding traits in their parents (r=0.32-0.43, p<.01). It is concluded that familial resemblance in bone structural strength and the position of an individual's bone traits relative to others in adulthood are likely to be established during the first year of life. Thus susceptibility to bone fragility late in life has its antecedents established early in life.

Original languageEnglish (US)
Pages (from-to)1512-1520
Number of pages9
JournalJournal of Bone and Mineral Research
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2010

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Bone and Bones
Population
Heel
Puberty
Crowns
Weights and Measures
Parents
Parturition
Compressive Strength
Densitometry
Femur Neck
Birth Weight
Fathers
Spine
Tomography
Pregnancy
Growth

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life. / Wang, Qingju; Alén, Markku; Lyytikäinen, Arja; Xu, Leiting; Tylavsky, Frances; Kujala, Urho M.; Kröger, Heikki; Seeman, Ego; Cheng, Sulin.

In: Journal of Bone and Mineral Research, Vol. 25, No. 7, 01.07.2010, p. 1512-1520.

Research output: Contribution to journalArticle

Wang, Qingju ; Alén, Markku ; Lyytikäinen, Arja ; Xu, Leiting ; Tylavsky, Frances ; Kujala, Urho M. ; Kröger, Heikki ; Seeman, Ego ; Cheng, Sulin. / Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life. In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 7. pp. 1512-1520.
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AU - Tylavsky, Frances

AU - Kujala, Urho M.

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