Fatal epstein-Barr virus myocarditis in a child with repetitive myocarditis

Michelle M. Hebert, Cecilia Yu, Jeffrey Towbin, Beverly Barton Rogers

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Fatal Epstein-Barr virus (EBV) myocarditis occurred in a 9-year-old female with a history of two prior discrete episodes of myocarditis, the first associated with chicken pox and the second of undetermined origin. Serologic studies during the fatal episode were characteristic of acute EBV infection, and EBV genome was detected by polymerase chain reaction (PCR) amplification of DNA extracted from cutopsy heart and liver. PCRs for enteroviruses and cardiac viral culture were negative. An intense mononuclear cell infiltrate in the myocardium consisted entirely of T cells, without identifiable B cells. Human leukocyte antigen HLA-DR analysis using frozen tissue obtained postmortem revealed antigens DR4 and DR13. DR4 is associated with some autoimmune disorders, as well as idiopathic dilated cardiomyopathy. We postulate that an aberrant immune response, possibly associated with the DR4 locus, was responsible for the repetitive episodes of myocarditis in this patient..

Original languageEnglish (US)
Pages (from-to)805-812
Number of pages8
JournalFetal and Pediatric Pathology
Volume15
Issue number5
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Myocarditis
Human Herpesvirus 4
Polymerase Chain Reaction
Epstein-Barr Virus Infections
Chickenpox
Enterovirus
Dilated Cardiomyopathy
HLA-DR Antigens
HLA Antigens
Myocardium
B-Lymphocytes
Genome
T-Lymphocytes
Antigens
Liver
DNA

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Fatal epstein-Barr virus myocarditis in a child with repetitive myocarditis. / Hebert, Michelle M.; Yu, Cecilia; Towbin, Jeffrey; Rogers, Beverly Barton.

In: Fetal and Pediatric Pathology, Vol. 15, No. 5, 01.01.1995, p. 805-812.

Research output: Contribution to journalArticle

Hebert, Michelle M. ; Yu, Cecilia ; Towbin, Jeffrey ; Rogers, Beverly Barton. / Fatal epstein-Barr virus myocarditis in a child with repetitive myocarditis. In: Fetal and Pediatric Pathology. 1995 ; Vol. 15, No. 5. pp. 805-812.
@article{83044036a4a64d9e84a59699f4aebb71,
title = "Fatal epstein-Barr virus myocarditis in a child with repetitive myocarditis",
abstract = "Fatal Epstein-Barr virus (EBV) myocarditis occurred in a 9-year-old female with a history of two prior discrete episodes of myocarditis, the first associated with chicken pox and the second of undetermined origin. Serologic studies during the fatal episode were characteristic of acute EBV infection, and EBV genome was detected by polymerase chain reaction (PCR) amplification of DNA extracted from cutopsy heart and liver. PCRs for enteroviruses and cardiac viral culture were negative. An intense mononuclear cell infiltrate in the myocardium consisted entirely of T cells, without identifiable B cells. Human leukocyte antigen HLA-DR analysis using frozen tissue obtained postmortem revealed antigens DR4 and DR13. DR4 is associated with some autoimmune disorders, as well as idiopathic dilated cardiomyopathy. We postulate that an aberrant immune response, possibly associated with the DR4 locus, was responsible for the repetitive episodes of myocarditis in this patient..",
author = "Hebert, {Michelle M.} and Cecilia Yu and Jeffrey Towbin and Rogers, {Beverly Barton}",
year = "1995",
month = "1",
day = "1",
doi = "10.3109/15513819509027016",
language = "English (US)",
volume = "15",
pages = "805--812",
journal = "Fetal and Pediatric Pathology",
issn = "1551-3815",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Fatal epstein-Barr virus myocarditis in a child with repetitive myocarditis

AU - Hebert, Michelle M.

AU - Yu, Cecilia

AU - Towbin, Jeffrey

AU - Rogers, Beverly Barton

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Fatal Epstein-Barr virus (EBV) myocarditis occurred in a 9-year-old female with a history of two prior discrete episodes of myocarditis, the first associated with chicken pox and the second of undetermined origin. Serologic studies during the fatal episode were characteristic of acute EBV infection, and EBV genome was detected by polymerase chain reaction (PCR) amplification of DNA extracted from cutopsy heart and liver. PCRs for enteroviruses and cardiac viral culture were negative. An intense mononuclear cell infiltrate in the myocardium consisted entirely of T cells, without identifiable B cells. Human leukocyte antigen HLA-DR analysis using frozen tissue obtained postmortem revealed antigens DR4 and DR13. DR4 is associated with some autoimmune disorders, as well as idiopathic dilated cardiomyopathy. We postulate that an aberrant immune response, possibly associated with the DR4 locus, was responsible for the repetitive episodes of myocarditis in this patient..

AB - Fatal Epstein-Barr virus (EBV) myocarditis occurred in a 9-year-old female with a history of two prior discrete episodes of myocarditis, the first associated with chicken pox and the second of undetermined origin. Serologic studies during the fatal episode were characteristic of acute EBV infection, and EBV genome was detected by polymerase chain reaction (PCR) amplification of DNA extracted from cutopsy heart and liver. PCRs for enteroviruses and cardiac viral culture were negative. An intense mononuclear cell infiltrate in the myocardium consisted entirely of T cells, without identifiable B cells. Human leukocyte antigen HLA-DR analysis using frozen tissue obtained postmortem revealed antigens DR4 and DR13. DR4 is associated with some autoimmune disorders, as well as idiopathic dilated cardiomyopathy. We postulate that an aberrant immune response, possibly associated with the DR4 locus, was responsible for the repetitive episodes of myocarditis in this patient..

UR - http://www.scopus.com/inward/record.url?scp=0029135037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029135037&partnerID=8YFLogxK

U2 - 10.3109/15513819509027016

DO - 10.3109/15513819509027016

M3 - Article

VL - 15

SP - 805

EP - 812

JO - Fetal and Pediatric Pathology

JF - Fetal and Pediatric Pathology

SN - 1551-3815

IS - 5

ER -