Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis

Diagnosis by polymerase chain reaction

Calvin E. Oyer, Emelie H. Ongcapin, Jiyuan Ni, Neil E. Bowles, Jeffrey Towbin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report a case of fatal hydrops fetalis owing to adenoviral endomyocarditis with aortic and pulmonary valve stenosis. A 1850-g macerated male stillborn delivered 1 week after fetal ultrasonography showed hydrops, cardiomegaly, and possible aortic valve stenosis. Autopsy confirmed hydrops and showed thickened, fibrotic semilunar valves with stenosis. The myocardium was focally fibrotic with areas of calcification. Polymerase chain reaction study of myocardial and aortic valve tissue was positive for adenovirus. Intrauterine viral myocarditis has been reported only rarely, but cases owing to Coxsackie B virus, adenovirus, and parvovirus B19 have appeared in the literature. With the exception of rubella, viral causation of significant valvular lesions in humans has received scanty support in the literature. This report suggests a broader group of causative agents. (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)1433-1435
Number of pages3
JournalHuman Pathology
Volume31
Issue number11
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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Pulmonary Valve Stenosis
Aortic Valve Stenosis
Adenoviridae
Edema
Prenatal Ultrasonography
Hydrops Fetalis
Human Enterovirus B
Polymerase Chain Reaction
Parvovirus
Rubella
Myocarditis
Cardiomegaly
Aortic Valve
Causality
Autopsy
Myocardium
Pathologic Constriction

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis : Diagnosis by polymerase chain reaction. / Oyer, Calvin E.; Ongcapin, Emelie H.; Ni, Jiyuan; Bowles, Neil E.; Towbin, Jeffrey.

In: Human Pathology, Vol. 31, No. 11, 01.01.2000, p. 1433-1435.

Research output: Contribution to journalArticle

Oyer, Calvin E. ; Ongcapin, Emelie H. ; Ni, Jiyuan ; Bowles, Neil E. ; Towbin, Jeffrey. / Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis : Diagnosis by polymerase chain reaction. In: Human Pathology. 2000 ; Vol. 31, No. 11. pp. 1433-1435.
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