Feasibility of SPECT for studies of brain perfusion during cardiopulmonary bypass

Sergei Marochnik, Andrei Alexandrov, David Anthone, Carl Lewin, Curtis B. Caldwell, Patrick M. Pullicino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Single-photon emission computed tomography (SPECT) and transcranial Doppler (TCD) ultrasonography were used to assess brain perfusion during cardiopulmonary bypass. Intravenous injections of technetium 99 m- hexamethylpropyleneamineoxime (99mTc-HMPAO) were administered before surgery and intraoperatively after the first 2 minutes in the first patient and at the end (42 minutes) of cardiopulmonary bypass in the second patient. The total middle cerebral artery territory counts were calculated using the region-of-interest method and compared to cerebellar regional counts. 99mTc-HMPAO uptake on SPECT scans was increased at the beginning and at the end of cardiopulmonary bypass, compared to baseline preoperative values (11-17%) in the presence of multiple microembolic signals on TCD (n1 = 35 and n2 = 42 for unilateral middle cerebral artery monitoring). These results indicate the feasibility of using HMPAO-SPECT to study brain perfusion changes during cardiac surgery. A combination of SPECT and TCD ultrasonography may be used to study the impact of microembolism during cardiac surgery with cardiopulmonary bypass.

Original languageEnglish (US)
Pages (from-to)243-245
Number of pages3
JournalJournal of Neuroimaging
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Single-Photon Emission-Computed Tomography
Cardiopulmonary Bypass
Perfusion
Technetium Tc 99m Exametazime
Doppler Transcranial Ultrasonography
Middle Cerebral Artery
Brain
Thoracic Surgery
Technetium
Intravenous Injections

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Feasibility of SPECT for studies of brain perfusion during cardiopulmonary bypass. / Marochnik, Sergei; Alexandrov, Andrei; Anthone, David; Lewin, Carl; Caldwell, Curtis B.; Pullicino, Patrick M.

In: Journal of Neuroimaging, Vol. 6, No. 4, 01.01.1996, p. 243-245.

Research output: Contribution to journalArticle

Marochnik, S, Alexandrov, A, Anthone, D, Lewin, C, Caldwell, CB & Pullicino, PM 1996, 'Feasibility of SPECT for studies of brain perfusion during cardiopulmonary bypass', Journal of Neuroimaging, vol. 6, no. 4, pp. 243-245. https://doi.org/10.1111/jon199664243
Marochnik, Sergei ; Alexandrov, Andrei ; Anthone, David ; Lewin, Carl ; Caldwell, Curtis B. ; Pullicino, Patrick M. / Feasibility of SPECT for studies of brain perfusion during cardiopulmonary bypass. In: Journal of Neuroimaging. 1996 ; Vol. 6, No. 4. pp. 243-245.
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