Feasibility study of multipinhole collimators for high resolution small animal imaging

Enrique Izaguirre, Mingshan Sun, James Carver, Bruce H. Hasegawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Multipinhole SPECT has the potential to overcome the inherent low efficiency of single pinhole gamma cameras typically used in small animal radionuclide imaging. By increasing the detector efficiency, multipinhole SPECT cameras allows to use reduced radionuclide dose and shorter scanning times than single pinhole gamma cameras. Reduced scanning times are advantageous for longitudinal studies where small animal models must be imaged several times. In addition, a spatial resolution of 1 mm or better is often required in drug delivery research and myocardial perfusion studies. In this article, we evaluate multipinhole collimator designs to obtain the best pinhole configuration that will increase the detector efficiency and maximize the use of a recently developed CZT with 128×128 pixels. Additionally the multipinhole design minimize the overlap of the projection data to avoid artifacts in the tomographic reconstructions. For this purpose, we simulated the acquisition of projection data from point sources, microspheres phantoms, and resolution phantoms, by using a in house developed Monte Carlo program which accounts for the gamma photons interactions with the pinhole and detector crystal. The generated projection data was reconstructed using a standard ML-EM algorithm adapted for multipinhole radionuclide imaging. We determined the multipinhole collimator efficiency, resolution, and signal to noise ratio for several possible multipinhole configurations. A design of five pinhole arrays allowed high efficiency imaging (3.93 fold) while achieving a spatial resolution of 1mm or better. Reconstruction of hot rod phantom data showed that a contrast of 90% between the hot rods and cold background was obtained after 45 iterations of the ML-EM algorithm.

Original languageEnglish (US)
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
Pages2963-2965
Number of pages3
Volume5
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: Oct 29 2006Nov 4 2006

Other

Other2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period10/29/0611/4/06

Fingerprint

Animals
Imaging techniques
Radioisotopes
Cameras
Detectors
Scanning
Microspheres
Drug delivery
Signal to noise ratio
Photons
Pixels
Crystals

All Science Journal Classification (ASJC) codes

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Izaguirre, E., Sun, M., Carver, J., & Hasegawa, B. H. (2007). Feasibility study of multipinhole collimators for high resolution small animal imaging. In 2006 IEEE Nuclear Science Symposium - Conference Record (Vol. 5, pp. 2963-2965). [4179654] https://doi.org/10.1109/NSSMIC.2006.356497

Feasibility study of multipinhole collimators for high resolution small animal imaging. / Izaguirre, Enrique; Sun, Mingshan; Carver, James; Hasegawa, Bruce H.

2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5 2007. p. 2963-2965 4179654.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Izaguirre, E, Sun, M, Carver, J & Hasegawa, BH 2007, Feasibility study of multipinhole collimators for high resolution small animal imaging. in 2006 IEEE Nuclear Science Symposium - Conference Record. vol. 5, 4179654, pp. 2963-2965, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 10/29/06. https://doi.org/10.1109/NSSMIC.2006.356497
Izaguirre E, Sun M, Carver J, Hasegawa BH. Feasibility study of multipinhole collimators for high resolution small animal imaging. In 2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5. 2007. p. 2963-2965. 4179654 https://doi.org/10.1109/NSSMIC.2006.356497
Izaguirre, Enrique ; Sun, Mingshan ; Carver, James ; Hasegawa, Bruce H. / Feasibility study of multipinhole collimators for high resolution small animal imaging. 2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5 2007. pp. 2963-2965
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