Features of intraventricular tanycytic ependymoma

Report of a case and review of literature

Shweta Agarwal, Michael E. Stevenson, Michael E. Sughrue, Eric P. Wartchow, Gary W. Mierau, Kar Ming Fung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Tanycytic ependymoma is the rarest variant of ependymoma and occurs primarily in the spinal cord. Intracranial cases are even rarer. Only 9 ventricular and 5 subcortical tanycytic ependymoma have been reported in the literature. Amongst the 9 ventricular cases, only one tumor arose from the third ventricle. We report here another case of tanycytic ependymoma arising from the third ventricle completed with immunohistochemical, ultrastructural, and molecular pathology study. The patient was a 44 year-old male who presented with headache, nausea and visual disturbances of a few months duration. Neuroradiological findings showed a well-defined mass arising from the posterolateral wall of third ventricle. Histologically the tumor was composed of monotonous spindle cells arranged in fascicles without definitive perivascular rosettes. The tumor cells were diffusely positive for glial fibrillary acidic protein and epithelial membrane antigen, showed faint immunoreactivity for synaptophysin but were negative for neurofilament proteins and Ki-67 was less than 1%. Molecular studies showed absence of isocitrate dehydrogenase gene 1 and 2 mutation. A diagnosis of tanycytic ependymoma (TE) was made. From literature review with our current case included, intraventricular tanycytic ependymomas ranged from 1.8 to 4.0 cm. The age of patients ranged from 3.5 to 75 years with a mean age of 37.5 and a male predominance. The tumors occurred as well-defined, solitary ventricular mass without significant peritumoral edema with or without cystic changes. Histopathology and immunohistochemical profile are rather similar among different tumors. The immediate to short term outcome is excellent but long term follow up data is lacking.

Original languageEnglish (US)
Pages (from-to)3399-3407
Number of pages9
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number6
StatePublished - Jan 1 2014
Externally publishedYes

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Ependymoma
Third Ventricle
Neoplasms
Neurofilament Proteins
Isocitrate Dehydrogenase
Mucin-1
Synaptophysin
Molecular Pathology
Glial Fibrillary Acidic Protein
Nausea
Headache
Edema
Spinal Cord
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

Cite this

Agarwal, S., Stevenson, M. E., Sughrue, M. E., Wartchow, E. P., Mierau, G. W., & Fung, K. M. (2014). Features of intraventricular tanycytic ependymoma: Report of a case and review of literature. International Journal of Clinical and Experimental Pathology, 7(6), 3399-3407.

Features of intraventricular tanycytic ependymoma : Report of a case and review of literature. / Agarwal, Shweta; Stevenson, Michael E.; Sughrue, Michael E.; Wartchow, Eric P.; Mierau, Gary W.; Fung, Kar Ming.

In: International Journal of Clinical and Experimental Pathology, Vol. 7, No. 6, 01.01.2014, p. 3399-3407.

Research output: Contribution to journalArticle

Agarwal, Shweta ; Stevenson, Michael E. ; Sughrue, Michael E. ; Wartchow, Eric P. ; Mierau, Gary W. ; Fung, Kar Ming. / Features of intraventricular tanycytic ependymoma : Report of a case and review of literature. In: International Journal of Clinical and Experimental Pathology. 2014 ; Vol. 7, No. 6. pp. 3399-3407.
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