Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat

Toshiie Sakata, Koichiro Tsutsui, Masataka Fukushima, Koichi Arase, Hitoshi Kita, Yutaka Oomura, Kosuke Ohki, Stylianos Nicolaidis

Research output: Contribution to journalArticle

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Abstract

1,5-Anhydroglucitol (1DG, minus an oxygen on carbon 1 of the glucose molecule), has been known physiologically to be present in human cerebrospinal fluid. In order to clarify direct evidence concerning 1DG-induced feeding, hyperglycemia and adrenomedullary mediation of hyperglycemia, 1DG was infused into rat lateral ventricle in doses of 11.8, 21.0, 33.7 and 50.0 μmoles/rat, and its effects compared to those of 2-deoxy-D-glucose (2DG). A dose-dependent increase in food intake after 1DG was 1/3.4 to 1/10.6 of that produced by equimolar 2DG. After 1DG serum glucose concentration gradually increased, peaked at 30 min, and subsequently decreased. Hyperglycemia induced by 1DG was 1/2.1 to 1/2.2 of that produced by 2 DG and was reduced 81% following adrenomedullectomy, which was close to the value for 2DG: 80%. Results were consistent with known differences in the biochemical actions of 1DG and 2DG at the level of substrate specificity of the hexokinase and the rate of glucose transport. These actions suggest that 1DG could provide physiological signals for food intake.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalPhysiology and Behavior
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1981

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Deoxyglucose
Hyperglycemia
Glucose
Mole Rats
Eating
Hexokinase
Lateral Ventricles
Substrate Specificity
Cerebrospinal Fluid
Carbon
Oxygen
1,5-anhydroglucitol
Serum

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Sakata, T., Tsutsui, K., Fukushima, M., Arase, K., Kita, H., Oomura, Y., ... Nicolaidis, S. (1981). Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat. Physiology and Behavior, 27(3), 401-405. https://doi.org/10.1016/0031-9384(81)90323-1

Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat. / Sakata, Toshiie; Tsutsui, Koichiro; Fukushima, Masataka; Arase, Koichi; Kita, Hitoshi; Oomura, Yutaka; Ohki, Kosuke; Nicolaidis, Stylianos.

In: Physiology and Behavior, Vol. 27, No. 3, 01.01.1981, p. 401-405.

Research output: Contribution to journalArticle

Sakata, T, Tsutsui, K, Fukushima, M, Arase, K, Kita, H, Oomura, Y, Ohki, K & Nicolaidis, S 1981, 'Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat', Physiology and Behavior, vol. 27, no. 3, pp. 401-405. https://doi.org/10.1016/0031-9384(81)90323-1
Sakata, Toshiie ; Tsutsui, Koichiro ; Fukushima, Masataka ; Arase, Koichi ; Kita, Hitoshi ; Oomura, Yutaka ; Ohki, Kosuke ; Nicolaidis, Stylianos. / Feeding and hyperglycemia induced by 1,5-anhydroglucitol in the rat. In: Physiology and Behavior. 1981 ; Vol. 27, No. 3. pp. 401-405.
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