Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase

George Cook, Bobby Khan, Murray Heimberg

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Administration of lovastatin to male, Sprague-Dawley rats by addition of the drug to the normal chow diet caused a two-fold increase in the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase, but lovastatin apparently did not affect the sensitivity of the outer carnitine palmitoyltransferase to inhibition by malonyl-CoA. There was also no effect of lovastatin on the activity of the hepatic mitochondrial inner carnitine palmitoyltransferase. Feeding of cholestyramine to rats did not affect either the mitochondrial outer carnitine palmitoyltransferase or the mitochondrial inner carnitine palmitoyltransferase.

Original languageEnglish (US)
Pages (from-to)1077-1082
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number3
DOIs
StatePublished - Feb 15 1988

Fingerprint

Carnitine O-Palmitoyltransferase
Lovastatin
Rats
Liver
Malonyl Coenzyme A
Cholestyramine Resin
Nutrition
Sprague Dawley Rats
Diet
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase. / Cook, George; Khan, Bobby; Heimberg, Murray.

In: Biochemical and Biophysical Research Communications, Vol. 150, No. 3, 15.02.1988, p. 1077-1082.

Research output: Contribution to journalArticle

@article{bf22b76be8764cab8be8771fe0e0130d,
title = "Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase",
abstract = "Administration of lovastatin to male, Sprague-Dawley rats by addition of the drug to the normal chow diet caused a two-fold increase in the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase, but lovastatin apparently did not affect the sensitivity of the outer carnitine palmitoyltransferase to inhibition by malonyl-CoA. There was also no effect of lovastatin on the activity of the hepatic mitochondrial inner carnitine palmitoyltransferase. Feeding of cholestyramine to rats did not affect either the mitochondrial outer carnitine palmitoyltransferase or the mitochondrial inner carnitine palmitoyltransferase.",
author = "George Cook and Bobby Khan and Murray Heimberg",
year = "1988",
month = "2",
day = "15",
doi = "10.1016/0006-291X(88)90739-5",
language = "English (US)",
volume = "150",
pages = "1077--1082",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase

AU - Cook, George

AU - Khan, Bobby

AU - Heimberg, Murray

PY - 1988/2/15

Y1 - 1988/2/15

N2 - Administration of lovastatin to male, Sprague-Dawley rats by addition of the drug to the normal chow diet caused a two-fold increase in the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase, but lovastatin apparently did not affect the sensitivity of the outer carnitine palmitoyltransferase to inhibition by malonyl-CoA. There was also no effect of lovastatin on the activity of the hepatic mitochondrial inner carnitine palmitoyltransferase. Feeding of cholestyramine to rats did not affect either the mitochondrial outer carnitine palmitoyltransferase or the mitochondrial inner carnitine palmitoyltransferase.

AB - Administration of lovastatin to male, Sprague-Dawley rats by addition of the drug to the normal chow diet caused a two-fold increase in the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase, but lovastatin apparently did not affect the sensitivity of the outer carnitine palmitoyltransferase to inhibition by malonyl-CoA. There was also no effect of lovastatin on the activity of the hepatic mitochondrial inner carnitine palmitoyltransferase. Feeding of cholestyramine to rats did not affect either the mitochondrial outer carnitine palmitoyltransferase or the mitochondrial inner carnitine palmitoyltransferase.

UR - http://www.scopus.com/inward/record.url?scp=0023829688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023829688&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(88)90739-5

DO - 10.1016/0006-291X(88)90739-5

M3 - Article

VL - 150

SP - 1077

EP - 1082

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -