Fe3O4@zirconium phosphate core-shell nanoparticles for pH-sensitive and magnetically guided drug delivery applications

Himani Kalita, Shashi Rajput, Prashanth Kumar Bhusetty Nagesh, Mahitosh Mandal, Amita Pathak

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study, biocompatible and magnetic Fe3O4@zirconium phosphate core-shell nanoparticles, comprising a magnetic Fe3O4 core and biocompatible zirconium phosphate shell, were prepared for pH-sensitive and magnetically guided drug delivery applications. The formation of the core-shell nanoparticles was affirmed from the XRD and FT-IR studies. TEM analysis revealed proper coverage of the zirconium phosphate shell on the magnetite core, while magnetic studies substantiated the superparamagnetic behavior of the nanoparticles. The suitability of the nanoparticles for intracellular application was validated through the conventional MTT assay, performed on human breast cancer cell lines (MDA-MB-231). The loading-release behavior of the antitumor drug, curcumin, on and from the core-shell nanoparticles respectively were studied by UV-Vis spectroscopy, where the drug-loaded particles showed pH-sensitive release profiles. The nanoformulated curcumin was found to exhibit enhanced cytotoxicity and better bioavailability in contrast to native curcumin.

Original languageEnglish (US)
Pages (from-to)21285-21292
Number of pages8
JournalRSC Advances
Volume6
Issue number25
DOIs
StatePublished - Jan 1 2016

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Drug delivery
Zirconium
Phosphates
Curcumin
Nanoparticles
Magnetic cores
Ferrosoferric Oxide
Magnetite
Cytotoxicity
Ultraviolet spectroscopy
Antineoplastic Agents
Assays
Cells
zirconium phosphate
Transmission electron microscopy
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Fe3O4@zirconium phosphate core-shell nanoparticles for pH-sensitive and magnetically guided drug delivery applications. / Kalita, Himani; Rajput, Shashi; Bhusetty Nagesh, Prashanth Kumar; Mandal, Mahitosh; Pathak, Amita.

In: RSC Advances, Vol. 6, No. 25, 01.01.2016, p. 21285-21292.

Research output: Contribution to journalArticle

Kalita, Himani ; Rajput, Shashi ; Bhusetty Nagesh, Prashanth Kumar ; Mandal, Mahitosh ; Pathak, Amita. / Fe3O4@zirconium phosphate core-shell nanoparticles for pH-sensitive and magnetically guided drug delivery applications. In: RSC Advances. 2016 ; Vol. 6, No. 25. pp. 21285-21292.
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